Recombinant Human GPX2, His-tagged GPX2-29071TH

Cat.No.:	GPX2-29071TH
Product Overview:	Recombinant full length protein, corresponding to amino acids 1-190 of Human Glutathione Peroxidase 2, with an N-terminal His tag. 210 amino acids with a predicted MWt of 22 kDa
Description:	This gene is a member of the glutathione peroxidase family and encodes a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract. Studies in knockout mice indicate that mRNA expression levels respond to luminal microflora, suggesting a role of the ileal glutathione peroxidases in preventing inflammation in the GI tract.
Protein length:	190 amino acids
Conjugation:	HIS
Molecular Weight:	24.100kDa inclusive of tags
Source:	E. coli
Tissue specificity:	Mostly in liver and gastrointestinal tract, not found in heart or kidney.
Form:	Liquid
Purity:	>95% by SDS-PAGE
Storage buffer:	pH: 7.50Constituents:0.32% Tris HCl, 0.88% Sodium chloride, 0.02% DTT, 40% Glycerol
Storage:	Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids:	MGSSHHHHHH SSGLVPRGSH MAFIAKSFYD LSAISLDGEK VDFNTFRGRA VLIENVASLC GTTTRDFTQL NELQCRFPRR LVVLGFPCNQ FGHQENCQNE EILNSLKYVR PGGGYQPTFT LVQKCEVNGQ NEHPVFAYLK DKLPYPYDDP FSLMTDPKLI IWSPVRRSDV AWNFEKFLIG PEGEPFRRYS RTFPTINIEP DIKRLLKVAI
Sequence Similarities:	Belongs to the glutathione peroxidase family.

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Gene Name:	GPX2 glutathione peroxidase 2 (gastrointestinal) [ Homo sapiens ]
Official Symbol:	GPX2
Synonyms:	GPX2; glutathione peroxidase 2 (gastrointestinal); glutathione peroxidase 2; GSHPX GI;
Gene ID:	2877
mRNA Refseq:	NM_002083
Protein Refseq:	NP_002074
MIM:	138319
Uniprot ID:	P18283
Chromosome Location:	14q24.1
Pathway:	Arachidonic acid metabolism, organism-specific biosystem; Arachidonic acid metabolism, conserved biosystem; Folate Metabolism, organism-specific biosystem; Glutathione metabolism, organism-specific biosystem; Glutathione metabolism, organism-specific biosystem;
Function:	electron carrier activity; glutathione peroxidase activity; oxidoreductase activity;