Recombinant Human GPX2, His-tagged

• Cat.No.: GPX2-29071TH
• Product Overview: Recombinant full length protein, corresponding to amino acids 1-190 of Human Glutathione Peroxidase 2, with an N-terminal His tag. 210 amino acids with a predicted MWt of 22 kDa

Specification

• Description: This gene is a member of the glutathione peroxidase family and encodes a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract. Studies in knockout mice indicate that mRNA expression levels respond to luminal microflora, suggesting a role of the ileal glutathione peroxidases in preventing inflammation in the GI tract.
• Protein length: 190 amino acids
• Conjugation: HIS
• Molecular Weight: 24.100kDa inclusive of tags
• Source: E. coli
• Tissue specificity: Mostly in liver and gastrointestinal tract, not found in heart or kidney.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: pH: 7.50Constituents:0.32% Tris HCl, 0.88% Sodium chloride, 0.02% DTT, 40% Glycerol
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MAFIAKSFYD LSAISLDGEK VDFNTFRGRA VLIENVASLC GTTTRDFTQL NELQCRFPRR LVVLGFPCNQ FGHQENCQNE EILNSLKYVR PGGGYQPTFT LVQKCEVNGQ NEHPVFAYLK DKLPYPYDDP FSLMTDPKLI IWSPVRRSDV AWNFEKFLIG PEGEPFRRYS RTFPTINIEP DIKRLLKVAI
• Sequence Similarities: Belongs to the glutathione peroxidase family.

Gene Information

• Gene Name: GPX2 glutathione peroxidase 2 (gastrointestinal) [ Homo sapiens ]
• Official Symbol: GPX2
• Synonyms: GPX2; glutathione peroxidase 2 (gastrointestinal); glutathione peroxidase 2; GSHPX GI
• Gene ID: 2877
• mRNA Refseq: NM_002083
• Protein Refseq: NP_002074
• MIM: 138319
• Uniprot ID: P18283
• Chromosome Location: 14q24.1
• Pathway: Arachidonic acid metabolism, organism-specific biosystem; Arachidonic acid metabolism, conserved biosystem; Folate Metabolism, organism-specific biosystem; Glutathione metabolism, organism-specific biosystem; Glutathione metabolism, organism-specific biosystem
• Function: electron carrier activity; glutathione peroxidase activity; oxidoreductase activity