Recombinant Human HRH1

• Cat.No.: HRH1-27712TH
• Product Overview: Recombinant full length Human Histamine H1 Receptor with N terminal FLAG tag and C terminal His tag, coexpressed with RGS4 , prepared from Sf9 cells coinfected with Human Histamine H1 Receptor and RGS4-encoding baculoviruses.

Specification

• Description: Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene was thought to be intronless until recently. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. Multiple alternatively spliced variants, encoding the same protein, have been identified.
• Conjugation: FLAG,His
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 75mM Tris HCl, 12.5mM Magnesium chloride, 1mM EDTA, pH 7.4
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.

Gene Information

• Gene Name: HRH1 histamine receptor H1 [ Homo sapiens ]
• Official Symbol: HRH1
• Synonyms: HRH1; histamine receptor H1; histamine H1 receptor
• Gene ID: 3269
• mRNA Refseq: NM_000861
• Protein Refseq: NP_000852
• MIM: 600167
• Uniprot ID: P35367
• Chromosome Location: 3p25
• Pathway: Amine ligand-binding receptors, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem
• Function: G-protein coupled receptor activity; histamine binding; histamine receptor activity; receptor activity; signal transducer activity