Recombinant Mouse FMS-like Tyrosine Kinase 3

• Cat.No.: Flt3-500M

Specification

• Cat. No.: Flt3-500M
• Description: Fms-Like tyrosine kinase 3 (FLT3) is a member of the class III tyrosine kinase receptor family, normally expressed in hematopoietic, immune and neural systems. FLT3 is expressed in various lymphohematopoietic cells and tissues, including a series of immature cell lines and leukemias of lymphocytic origin. FLT3 is a promising target for the therapeutic intervention for acute leukemias, particularly acute myeloid leukemia (AML) which are severe and aggressive malignancy.
• Molecular Weight: The predicted molecular weight of Recombinant Mouse Flt-3 is Mr 85 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 116 kDa.
• Source: Mammalian cells
• State Of Matter: Lyophilized.
• Purity: >95% by SDS Page and analyzed by silver stain.
• Endotoxin: <0.1 ng per 1 µg as determined by the LAL method.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: Flt3 FMS-like tyrosine kinase 3 [ Mus musculus ]
• Synonyms: Flt3; FMS-like tyrosine kinase 3; Flk2; Ly72; CD135; Flk-2; Flt-3; MGC124377; MGC124378; B230315G04; OTTMUSP00000022189; EC 2.7.10.1
• Gene ID: 14255
• mRNA Refseq: NM_010229
• Protein Refseq: NP_034359
• UniProt ID: Q00342
• Chromosome Location: 5 G3; 5 82.0 cM
• Pathway: Acute myeloid leukemia; Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Pathways in cancer
• Function: ATP binding; kinase activity; nucleotide binding; phosphoinositide 3-kinase binding; protein binding; protein kinase activity ; protein tyrosine kinase activity; receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity