Recombinant Human HSPA1B, His-tagged


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Recombinant Human HSPA1B, His-tagged

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Cat.No. : HSPA1B-29395TH
Product Overview : Recombinant full length human Hsp70 cloned from a human cDNA library with His tag.
Description : This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.
Conjugation : HIS
Source : E. coli
Tissue specificity : HSPA1B is testis-specific.
Biological activity : HSPA1B-29395TH has ATPase activity at the time of manufacture of 3.3μM phosphate liberated/hr/μg protein in a 200μl reaction at 37°C (pH7.5) in thepresence of 20ul of 1mM ATP using a Malachite Green assay.
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: 200mM ImidazoleConstituents: 10% Glycerol, 20mM Sodium phosphate, 150mM Sodium chloride, pH 7.5
Storage : Store at -20°C. Stable for 12 months at -20°C
Sequence Similarities : Belongs to the heat shock protein 70 family.
Gene Name : HSPA1B heat shock 70kDa protein 1B [ Homo sapiens ]
Official Symbol : HSPA1B
Synonyms : HSPA1B; heat shock 70kDa protein 1B; heat shock 70kD protein 1B; heat shock 70 kDa protein 1A/1B; HSP70 2;
Gene ID : 3304
mRNA Refseq : NM_005346
Protein Refseq : NP_005337
MIM : 603012
Uniprot ID : P08107
Chromosome Location : 6p21.3
Pathway : Androgen Receptor Signaling Pathway, organism-specific biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Apoptosis Modulation by HSP70, organism-specific biosystem; Destabilization of mRNA by AUF1 (hnRNP D0), organism-specific biosystem;
Function : ATP binding; nucleotide binding; protein N-terminus binding; protein binding; protein binding involved in protein folding;

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