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Recombinant Human ING5, His-tagged

Cat.No. : ING5-27620TH
Product Overview : Recombinant fragment, corresponding to amino acids 2-240 of Human ING5 with N terminal His tag; 239 amino acids, kDa.
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  • Gene Information
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Description : The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway.
Conjugation : HIS
Source : E. coli
Form : Lyophilised:Reconstitute with 71 μl aqua dest.
Storage buffer : Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
Storage : Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : ATAMYLEHYLDSIENLPCELQRNFQ LMRELDQRTEDKKAE IDILAAEYISTVKTLSPDQRVERLQ KIQNAYSKCKEYS DDKVQLAMQTYEMVDKHIRRLDADL ARFEADLKDKMEGSDFESSGGRGLK KGRGQKEKRGSRGRGRRTSEEDTPK KKK HKGGSEFTDTILSVHPSDVLDMPVD PNEPTYCLCHQVS YGEMIGCDNPDCPIEWFHFACVDLT TKPKGKWFCPRCVQEKRKKK
Gene Name : ING5 inhibitor of growth family, member 5 [ Homo sapiens ]
Official Symbol : ING5
Synonyms : ING5; inhibitor of growth family, member 5; inhibitor of growth protein 5; FLJ23842; p28ING5;
Gene ID : 84289
mRNA Refseq : NM_032329
Protein Refseq : NP_115705
MIM : 608525
Uniprot ID : Q8WYH8
Chromosome Location : 2q37.3
Function : metal ion binding; methylated histone residue binding; protein binding; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Does ING5 interact with specific histone modifications? 08/18/2021

Yes, ING5 is known to interact with specific histone modifications, including histone H3 trimethylated at Lysine 4 (H3K4me3).

What is the relevance of ING5’s interaction with H3K4me3? 06/22/2021

The interaction between ING5 and H3K4me3 is important for targeting specific chromatin regions and regulating gene expression.

How does ING5 contribute to chromatin remodeling? 06/30/2020

ING5 is known to interact with chromatin remodeling complexes, facilitating changes in chromatin structure and gene expression.

Can ING5 function as a tumor suppressor? 01/30/2019

Yes, ING5 has been identified as a potential tumor suppressor, and its loss or dysfunction can contribute to tumorigenesis.

How does ING5 influence cell cycle regulation? 09/30/2017

ING5 is involved in cell cycle control, and its expression can impact cell proliferation and the cell cycle progression of cells.

What is the primary function of ING5 protein in chromatin regulation? ING5 is a chromatin regulator that plays a role in transcriptional regulation and epigenetic processes. 11/21/2016

ING5 is a chromatin regulator that plays a role in transcriptional regulation and epigenetic

Are there any known genetic mutations or alterations associated with ING5 in cancer? 07/02/2016

Mutations or alterations in ING5 have been reported in various cancer types, suggesting its potential role in cancer development.

Customer Reviews (3)

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Reviews
09/24/2022

    The knowledge gained from the product's usage justified its cost, marking a prudent investment in our research endeavors.

    12/15/2016

      Despite its cost, the product's contributions to our research goals made it an invaluable asset.

      05/18/2016

        The product's adaptability to various buffers contributed to its stable and reliable performance.

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