Recombinant Human IRF1, His-tagged

• Cat.No.: IRF1-29246TH
• Product Overview: Recombinant fragment, corresponding to amino acids 1-114 of Human IRF1 with a His Tag of 20 aa, 15 kDa.

Specification

• Description: IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion.
• Conjugation: HIS
• Source: E. coli
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 20mM Tris, pH 8
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MPITRMRMRP WLEMQINSNQ IPGLIWINKE EMIFQIPWKHAAKHGWDINK DACLFRSWAI HTGRYKAGEK EPDPKTWKAN FRCAMNSLPD IEEVKDQSRN KGSSAVRVYR MLPP
• Sequence Similarities: Belongs to the IRF family.Contains 1 IRF tryptophan pentad repeat DNA-binding domain.

Gene Information

• Gene Name: IRF1 interferon regulatory factor 1 [ Homo sapiens ]
• Official Symbol: IRF1
• Synonyms: IRF1; interferon regulatory factor 1; MAR
• Gene ID: 3659
• mRNA Refseq: NM_002198
• Protein Refseq: NP_002189
• MIM: 147575
• Uniprot ID: P10914
• Chromosome Location: 5q23-q31
• Pathway: Apoptosis, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Factors involved in megakaryocyte development and platelet production, organism-specific biosystem; Glucocorticoid receptor regulatory network, organism-specific biosystem; Hemostasis, organism-specific biosystem
• Function: regulatory region DNA binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity