"IGFBP7" Related Products

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Recombinant Human IGFBP7, His-tagged

Cat. No.: IGFBP7-1630H
Product Overview: Recombinant Human Human IGFBP-rp1 (Asp 30 -Leu 282) encoding the signal peptide from human CD33 (Met 1 - Ala 16) was fused to the N-terminal 10X his tagged mature human IGFBP-rp1 (Asp 30 - Leu 282) and inserted into a suitable expression vector. The recombinant protein was expressed in a mouse myeloma cell line,NSO.
Description: Insulin-like growth factor binding protein 7, also known as IGFBP7 is a secretory protein. It is abundantly expressed in the uterine endometrium during the secretory phase of the menstrual cycle. Decreased IGFBP7 expression has been observed in some cancers and leiomyomata.IGFBP7 plays a potential tumor suppressor role in colorectal carcinogenesis.
Source: NSO Cells.
State Of Matter: Lyophilized.
Purity: >90% by SDS Page and analyzed by silver stain.
Endotoxin: <1.0 EU/µg as determined by the LAL method.
Molecular Weight: The predicted molecular weight of Recombinant Human IGF-BP7 is Mr 27.5 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 36 kDa.
Formulation: This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives present.
Biological Activity: The biological activity of Human IGF-BP7 was determined by by its ability to bind rh6Ckine/CCL21. Immobilized rhIGFBP-rp1 at 1 μg/mL (100 μL/well) can bind rh6Ckine/CCL21 with a linear range of 0.08 - 5 ng/mL in a functional ELISA.
Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Gene Name: IGFBP7 insulin-like growth factor binding protein 7 [ Homo sapiens ]
Synonyms: insulin-like growth factor binding protein 7; PSF; FSTL2; MAC25; IGFBP-7; IGFBP-7v; IGFBPRP1; IGFBP7; IBP-7; IGFBP-rP1; TAF; IGF-binding protein 7; MAC25 protein; PGI2-stimulating factor; Prostacyclin-stimulating factor; Tumor-derived adhesion factor
Gene ID: 3490
mRNA Refseq: NM_001553
Protein Refseq: NP_001544
MIM: 602867
UniProt ID: Q16270
Chromosome Location: 4q12
Function: insulin-like growth factor binding

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