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Recombinant Human IGFBP7, His-tagged

Cat.No. : IGFBP7-1630H
Product Overview : Recombinant Human Human IGFBP-rp1 (Asp 30 -Leu 282) encoding the signal peptide from human CD33 (Met 1 - Ala 16) was fused to the N-terminal 10X his tagged mature human IGFBP-rp1 (Asp 30 - Leu 282) and inserted into a suitable expression vector. The recombinant protein was expressed in a mouse myeloma cell line,NSO.
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Cat. No. : IGFBP7-1630H
Description : Insulin-like growth factor binding protein 7, also known as IGFBP7 is a secretory protein. It is abundantly expressed in the uterine endometrium during the secretory phase of the menstrual cycle. Decreased IGFBP7 expression has been observed in some cancers and leiomyomata.IGFBP7 plays a potential tumor suppressor role in colorectal carcinogenesis.
Source : Mammalian cells
State Of Matter : Lyophilized.
Purity : >90% by SDS Page and analyzed by silver stain.
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Molecular Weight : The predicted molecular weight of Recombinant Human IGF-BP7 is Mr 27.5 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 36 kDa.
Formulation : This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives present.
Biological Activity : The biological activity of Human IGF-BP7 was determined by by its ability to bind rh6Ckine/CCL21. Immobilized rhIGFBP-rp1 at 1 μg/mL (100 μL/well) can bind rh6Ckine/CCL21 with a linear range of 0.08 - 5 ng/mL in a functional ELISA.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Gene Name : IGFBP7 insulin-like growth factor binding protein 7 [ Homo sapiens ]
Synonyms : insulin-like growth factor binding protein 7; PSF; FSTL2; MAC25; IGFBP-7; IGFBP-7v; IGFBPRP1; IGFBP7; IBP-7; IGFBP-rP1; TAF; IGF-binding protein 7; MAC25 protein; PGI2-stimulating factor; Prostacyclin-stimulating factor; Tumor-derived adhesion factor
Gene ID : 3490
mRNA Refseq : NM_001553
Protein Refseq : NP_001544
MIM : 602867
UniProt ID : Q16270
Chromosome Location : 4q12
Function : insulin-like growth factor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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In what types of cancer is IGFBP7 research particularly focused? 07/30/2021

Research on IGFBP7 is often concentrated in breast, lung, prostate, and colorectal cancers, among others.

How does IGFBP7 contribute to cardiovascular health? 12/29/2020

IGFBP7 has been associated with cardiovascular health, and its potential role in protecting against cardiovascular diseases is an area of ongoing research.

Can IGFBP7 be used in therapeutic interventions? 12/04/2020

The potential therapeutic applications of IGFBP7 are being explored, including its use in targeted cancer therapies and other medical interventions.

Can IGFBP7 serve as a biomarker for cancer detection? 09/20/2018

Some studies suggest that IGFBP7 levels in blood or tissues may have potential as a biomarker for cancer detection.

How does IGFBP7 affect cell cycle regulation? 05/11/2018

IGFBP7 has been shown to influence the cell cycle by promoting cell cycle arrest, which can be crucial in preventing uncontrolled cell growth.

Customer Reviews (3)

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Reviews
04/09/2017

    Its purity and stability ensure consistent and accurate results, making it an ideal tool for my research endeavors.

    11/02/2016

      The manufacturer's commitment to maintaining stringent quality control measures guarantees that I can trust the protein's integrity and reliability throughout my experiments.

      09/19/2016

        This partnership enhances research productivity while ensuring accurate and meaningful outcomes.

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