Recombinant Human KPNA1

• Cat.No.: KPNA1-31462TH
• Product Overview: Recombinant full length Human SRP1 with a N terminal proprietary tag; predcited MW: 84.92 kDa, inclusive of tag. AAH02374.1, P52294.

Specification

• Description: Recombination activating proteins RAG1 and RAG2 regulate and mediate V(D)J recombination, the process by which genes for immunoglobulins and T-cell receptors are generated. Several other ubiquitously expressed proteins are thought to be recruited in the recombination process. Among these are the genes affected in severe combined immune deficiency and genes involved in ds-DNA break repair. The protein encoded by this gene interacts with RAG1 and may play a role in V(D)J recombination. Two transcript variants, one protein-coding and the other not, have been found for this gene.
• Protein length: 538 amino acids
• Molecular Weight: 84.920kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Expressed ubiquitously.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MTTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKR EEQLFKRRNVATAEEETEEEVMSDGGFHEAQINNMEMAPG GVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDE VISTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSL QTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDS TMCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLC RGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSY LSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAV GNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACW TISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEA AWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDSKIV QVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDK IEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQVDLN QQQYIFQQCEAPMEGFQL
• Sequence Similarities: Belongs to the importin alpha family.Contains 10 ARM repeats.Contains 1 IBB domain.

Gene Information

• Gene Name: KPNA1 karyopherin alpha 1 (importin alpha 5) [ Homo sapiens ]
• Official Symbol: KPNA1
• Synonyms: KPNA1; karyopherin alpha 1 (importin alpha 5); importin subunit alpha-1; IPOA5; NPI 1; RCH2; SRP1
• Gene ID: 3836
• mRNA Refseq: NM_002264
• Protein Refseq: NP_002255
• MIM: 600686
• Uniprot ID: P52294
• Chromosome Location: 3q21
• Pathway: Activation of DNA fragmentation factor, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis induced DNA fragmentation, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; Class I PI3K signaling events mediated by Akt, organism-specific biosystem
• Function: nuclear localization sequence binding; protein binding; protein transporter activity