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Recombinant Human KPNA1 Protein (8-538 aa), His-tagged

Cat.No. : KPNA1-608H
Product Overview : Recombinant Human KPNA1 Protein (8-538 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Protein Description: Partial.
  • Specification
  • Gene Information
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Description : Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Source : E. coli
Species : Human
Tag : His
Form : Tris-based buffer, 50% glycerol
Molecular Mass : 63.5 kDa
Protein length : 8-538 aa
AA Sequence : NFRLKSYKNKSLNPDEMRRRREEEG LQLRKQKREEQLFKRRNVATAEEET EEEVMSDGGFHEAQISNMEMAPGGV ITSDMIEMIFSKSPEQQLSATQKFR KLLSKEPNPPIDEVISTPGVVARFV EFLKRKENCTLQFESAWVLTNIASG NSLQTRIVIQAGAVPIFIELLSSEF EDVQEQAVWALGNIAGDSTMCRDYV LDCNILPPLLQLFSKQNRLTMTRNA VWALSNLCRGKSPPPEFAKVSPCLN VLSWLLFVSDTDVLADACWALSYLS DGPNDKIQAVIDAGVCRRLVELLMH NDYKVVSPALRAVGNIVTGDDIQTQ VILNCSALQSLLHLLSSPKESIKKE ACWTISNITAGNRAQIQTVIDANIF PALISILQTAEFRTRKEAAWAITNA TSGGSAEQIKYLVELGCIKPLCDLL TVMDSKIVQVALNGLENILRLGEQE AKRNGTGINPYCALIEEAYGLDKIE FLQSHENQEIYQKAFDLIEHYFGTE DEDSSIAPQVDLNQQQYIFQQCEAP MEGFQL
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with concentration instruction is sent along with the products.
Gene Name : KPNA1 karyopherin alpha 1 (importin alpha 5) [ Homo sapiens ]
Official Symbol : KPNA1
Synonyms : KPNA1; IPOA5; NPI 1; RCH2; SRP1; SRP1-beta; importin alpha 5; NPI-1;
Gene ID : 3836
mRNA Refseq : NM_002264
Protein Refseq : NP_002255
MIM : 600686
UniProt ID : P52294

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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