Recombinant Human KPNA1 Protein (8-538 aa), His-tagged
Cat.No. : | KPNA1-608H |
Product Overview : | Recombinant Human KPNA1 Protein (8-538 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Protein Description: Partial. |
- Specification
- Gene Information
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Description : | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Tris-based buffer, 50% glycerol |
Molecular Mass : | 63.5 kDa |
Protein length : | 8-538 aa |
AA Sequence : | NFRLKSYKNKSLNPDEMRRRREEEG LQLRKQKREEQLFKRRNVATAEEET EEEVMSDGGFHEAQISNMEMAPGGV ITSDMIEMIFSKSPEQQLSATQKFR KLLSKEPNPPIDEVISTPGVVARFV EFLKRKENCTLQFESAWVLTNIASG NSLQTRIVIQAGAVPIFIELLSSEF EDVQEQAVWALGNIAGDSTMCRDYV LDCNILPPLLQLFSKQNRLTMTRNA VWALSNLCRGKSPPPEFAKVSPCLN VLSWLLFVSDTDVLADACWALSYLS DGPNDKIQAVIDAGVCRRLVELLMH NDYKVVSPALRAVGNIVTGDDIQTQ VILNCSALQSLLHLLSSPKESIKKE ACWTISNITAGNRAQIQTVIDANIF PALISILQTAEFRTRKEAAWAITNA TSGGSAEQIKYLVELGCIKPLCDLL TVMDSKIVQVALNGLENILRLGEQE AKRNGTGINPYCALIEEAYGLDKIE FLQSHENQEIYQKAFDLIEHYFGTE DEDSSIAPQVDLNQQQYIFQQCEAP MEGFQL |
Purity : | > 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
Storage : | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
Concentration : | A hardcopy of COA with concentration instruction is sent along with the products. |
Gene Name : | KPNA1 karyopherin alpha 1 (importin alpha 5) [ Homo sapiens ] |
Official Symbol : | KPNA1 |
Synonyms : | KPNA1; IPOA5; NPI 1; RCH2; SRP1; SRP1-beta; importin alpha 5; NPI-1; |
Gene ID : | 3836 |
mRNA Refseq : | NM_002264 |
Protein Refseq : | NP_002255 |
MIM : | 600686 |
UniProt ID : | P52294 |
Products Types
◆ Recombinant Protein | ||
KPNA1-4898H | Recombinant Human KPNA1 Protein, GST-tagged | +Inquiry |
KPNA1-1260H | Recombinant Human KPNA1 Protein, His (Fc)-Avi-tagged | +Inquiry |
KPNA1-2261R | Recombinant Rhesus Macaque KPNA1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Kpna1-1278M | Recombinant Mouse Kpna1 Protein, MYC/DDK-tagged | +Inquiry |
KPNA1-4895M | Recombinant Mouse KPNA1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
KPNA1-4892HCL | Recombinant Human KPNA1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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