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Recombinant Human LMX1A

Cat.No. : LMX1A-29601TH
Product Overview : Recombinant full length Human LMX1A (aa 1-100) with N-terminal proprietary tag, 37.07 kDa.
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Description : Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene (INS; MIM 176730) and interact with RNA polymerase to activate or repress transcription. LMX1 is a homeodomain protein that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin (German et al.
Protein length : 100 amino acids
Molecular Weight : 37.070kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Isoform 1 is expressed in many tissues. Not found in heart, liver, spleen and testis. Relatively highly expressed in fetal brain. Isoform LMX1A-4B is expressed in testis.
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : MEGIMNPYTALPTPQQLLAIEQSVY SSDPFRQGLTPPQMPGDHMHPYGAE PLFHDLDSDDTSLSNLGDCFLATSE AGPLQSRVGNPIDHLYSMQNSYFTS
Sequence Similarities : Contains 1 homeobox DNA-binding domain.Contains 2 LIM zinc-binding domains.
Gene Name : LMX1A LIM homeobox transcription factor 1, alpha [ Homo sapiens ]
Official Symbol : LMX1A
Synonyms : LMX1A; LIM homeobox transcription factor 1, alpha; LMX1; LIM homeobox transcription factor 1-alpha; LMX1.1;
Gene ID : 4009
mRNA Refseq : NM_001174069
Protein Refseq : NP_001167540
MIM : 600298
Uniprot ID : Q8TE12
Chromosome Location : 1q24.1
Function : metal ion binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; zinc ion binding;

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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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