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Recombinant Human LOXL2 protein, FLAG-tagged

Cat.No. : LOXL2-29651TH
Product Overview : Recombinant Human LOXL2(500–end) fused with FLAG tag at C-terminal was expressed in Insect cells.
  • Specification
  • Gene Information
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Description : This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
Source : Insect cells
Species : Human
Tag : FLAG
Form : 40 mM Tris HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, and 20% glycerol.
Molecular Mass : 32 kDa
Applications : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage : >6 months at –80 centigrade. Avoid freeze/thaw cycles.
Concentration : 0.07mg/ml
Gene Name : LOXL2 lysyl oxidase-like 2 [ Homo sapiens ]
Official Symbol : LOXL2
Synonyms : LOXL2; lysyl oxidase-like 2; lysyl oxidase homolog 2; WS9 14; lysyl oxidase related 2; lysyl oxidase-like protein 2; lysyl oxidase-related protein 2; lysyl oxidase-related protein WS9-14; LOR2; WS9-14;
Gene ID : 4017
mRNA Refseq : NM_002318
Protein Refseq : NP_002309
MIM : 606663
UniProt ID : Q9Y4K0
Chromosome Location : 8p21.3
Function : copper ion binding; electron carrier activity; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor; scavenger receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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In what ways does LOXL2 impact tissue elasticity, and how is this relevant in clinical applications? 06/14/2021

LOXL2 promotes the cross-linking of elastin fibers, affecting tissue elasticity. Understanding these mechanisms can have implications in diseases where tissue flexibility is crucial, such as in cardiovascular conditions.

How does LOXL2 influence wound healing, and can it be targeted for therapeutic interventions? 03/04/2021

LOXL2 is involved in tissue repair and wound healing by modulating the extracellular matrix. Targeting LOXL2 may offer therapeutic opportunities to enhance or control the wound healing process.

Are there diagnostic applications of LOXL2 in clinical settings? 05/03/2020

Elevated levels of LOXL2 have been associated with certain diseases. Measuring LOXL2 levels can potentially serve as a diagnostic marker for conditions such as liver fibrosis and certain cancers.

Are there ongoing clinical trials targeting LOXL2 for therapeutic purposes? 06/08/2019

Yes, several clinical trials are exploring the potential of LOXL2 inhibitors in treating fibrosis and cancer. These trials aim to validate the efficacy and safety of targeting LOXL2 in clinical settings.

How does LOXL2 contribute to the clinical understanding of fibrosis? 06/28/2017

LOXL2 is implicated in fibrosis as it plays a key role in collagen cross-linking, influencing tissue stiffness and architecture, making it a potential target for anti-fibrotic therapies.

Customer Reviews (3)

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Reviews
06/20/2022

    This protein exhibits outstanding performance in ELISA, providing accurate and reliable results in detecting and quantifying specific antigens.

    01/16/2022

      Its high sensitivity ensures the detection of even low abundance targets, making it a valuable tool in immunoassays.

      03/23/2016

        Its stability and compatibility with electron microscopy techniques make it an excellent choice for studying protein structures at high resolution.

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