Recombinant Human MAP2K6

• Cat.No.: MAP2K6-30189TH
• Product Overview: Recombinant fragment, corresponding to amino acids 2-334 of Human MEK6 with N-terminal proprietary tag expressed in a Baculovirus infected Sf9 cell expression system, 63.5 kDa.

Specification

• Description: This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
• Source: Baculovirus
• Tissue specificity: Isoform 2 is only expressed in skeletal muscle. Isoform 1 is expressed in skeletal muscle, heart, and in lesser extent in liver or pancreas.
• Biological activity: Enzyme reaction is conducted in a buffer containing 50 mM HEPES (pH7.5), 10 mM MgCl2, 1 mM EGTA, 200 μM ATP, 0.01% Brij-35, 100ng of inactive MAPK14 and 2 μM substrate (SER/THR 4) at room temperature for 1 hour. Developer solution was added to reaction an
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.Contains 1 protein kinase domain.

Gene Information

• Gene Name: MAP2K6 mitogen-activated protein kinase kinase 6 [ Homo sapiens ]
• Official Symbol: MAP2K6
• Synonyms: MAP2K6; mitogen-activated protein kinase kinase 6; PRKMK6; dual specificity mitogen-activated protein kinase kinase 6; MAPKK6; MEK6; MKK6; protein kinase; mitogen activated; kinase 6 (MAP kinase kinase 6); SAPKK3
• Gene ID: 5608
• mRNA Refseq: NM_002758
• Protein Refseq: NP_002749
• MIM: 601254
• Uniprot ID: P52564
• Chromosome Location: 17q
• Pathway: Activated TLR4 signalling, organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; CDC42 signaling events, organism-specific biosystem; CDO in myogenesis, organism-specific biosystem
• Function: ATP binding; MAP kinase kinase activity; nucleotide binding; protein kinase binding; protein serine/threonine kinase activity