Recombinant Human IL5
Cat.No. : | IL5-214H |
Product Overview : | Recombinant Human interleukin 5 (colony-stimulating factor, eosinophil) DNA sequence encoding the human IL-5 protein sequence containing two 115 amino acid peptide chains was inserted into a suitable expression vector and was expressed inSf21 insect cells. |
- Specification
- Gene Information
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Cat. No. : | IL5-214H |
Description : | Interleukin 5 or IL-5 is an interleukin produced by T helper-2 cells and mast cells. Its functions are to stimulate B cell growth and increase immunoglobulin secretion. It is the main factor that promotes the terminal differentiation of eosinophil progenitors and enhances the effector capacity of mature eosinophils. IL-5 is a TH2 cytokine which is part of the hematopoietic family. Unlike other members of this cytokine family in its active form, this glycoprotein is a homodimer. IL-5 expression is regulated by several transcription factors including GATA-3. |
Source : | Sf21 Insect Cells. |
Molecular Weight : | The predicted molecular weight of Recombinant Human IL-5 is Mr 32-34 kDa. |
State Of Matter : | Solution. |
Formulation : | This recombinant protein solution was 0.2 µm filtered and formulated in modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives present. |
Purity : | >97% by SDS Page and analyzed by silver stain. |
Endotoxin : | <1.0 EU/µg as determined by the LAL method. |
Biological Activity : | The biological activity of Human IL-5 was determined in a cell proliferation assay using a factor-dependent human cell line, TF-1. The expected ED50 for this effect is typically 0.1 - 0.2 ng/mL. |
Storage And Stability : | Working aliquots of this recombinant protein solution are stable for up to twelve months at -20˚C to -70˚C in a manual defrost freezer. Upon thawing, in the presence of a carrier protein, this recombinant protein can be stored at 2˚C - 8˚C for one month without detectable loss of activity. For long-term storage, aliquot and freeze at -20˚C to -70˚C in a manual defrost freezer. Avoid repeated freeze thaw cycles. |
Gene Name : | IL5 interleukin 5 (colony-stimulating factor, eosinophil) [ Homo sapiens ] |
Synonyms : | IL5; interleukin 5 (colony-stimulating factor, eosinophil); EDF; IL-5; TRF; B cell differentiation factor I; T-cell replacing factor; eosinophil differentiation factor; interleukin 5; interleukin-5; B-cell differentiation factor I; Eosinophil differentiation factor; OTTHUMP00000065830 |
Gene ID : | 3567 |
mRNA Refseq : | NM_000879 |
Protein Refseq : | NP_000870 |
UniProt ID : | P05113 |
Chromosome Location : | 5q31.1 |
MIM : | 147850 |
Pathway : | Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Hematopoietic cell lineage; Allograft rejection; Asthma; Autoimmune thyroid disease; Fc epsilon RI signaling pathway; T cell receptor signaling pathway |
Function : | interleukin-5 receptor activity; cytokine activity; growth factor activity |
Products Types
◆ Lysates | ||
IL5-456CCL | Recombinant Canine IL5 cell lysate | +Inquiry |
IL5-496MCL | Recombinant Mouse IL5 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionInhibit the creatinine kinase level in the blood of patients with tuberous sclerosis, reduce the inflammatory response, and improve the quality of life of patients.
IL5 can reduce the number of eosinophils in the nasal mucosa of patients with allergic rhinitis, reducing the symptoms of allergic reactions, such as sneezing, runny nose and nasal congestion.
Stimulate the proliferation and differentiation of white blood cells, promote the function of the immune system, and is used to treat diseases such as asthma, allergic rhinitis, nodular sclerosis and some malignant tumors.
Cause mild side effects such as headache, nausea, vomiting, and serious side effects such as allergic reactions if the dose is too large or allergic.
IL5 cannot be administered orally, only by injection or intravenous drip.
IL5 can reduce the number of eosinophils in the lungs of asthma patients, reduce the frequency and severity of asthma attacks, and improve the quality of life of patients.
Customer Reviews (3)
Write a reviewHigh efficacy and safety in clinical treatment.
There are no structural or functional defects.
The stability and activity are maintained well during long-term storage.
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