Recombinant Human MC1R

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Recombinant Human MC1R

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Cat.No. : MC1R-29451TH
Product Overview : Recombinant fragment, corresponding to amino acids 1-100 of Human MC1 Receptor, with an N-terminal proprietary tag, predicted MWt 36.63 kDa
Description : This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.
Protein length : 100 amino acids
Molecular Weight : 36.630kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Melanocytes and corticoadrenal tissue.
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : MAVQGSQRRL LGSLNSTPTA IPQLGLAANQ TGARCLEVSI SDGLFLSLGL VSLVENALVV ATIAKNRNLH SPMYCFICCL ALSDLLVSGS NVLETAVILL
Sequence Similarities : Belongs to the G-protein coupled receptor 1 family.
Gene Name : MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) [ Homo sapiens ]
Official Symbol : MC1R
Synonyms : MC1R; melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor); melanocyte-stimulating hormone receptor; MSH R;
Gene ID : 4157
mRNA Refseq : NM_002386
Protein Refseq : NP_002377
MIM : 155555
Uniprot ID : Q01726
Chromosome Location : 16q24.3
Pathway : Chaperonin-mediated protein folding, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cooperation of Prefoldin and TriC/CCTin actin and tubulin folding, organism-specific biosystem; Diurnally regulated genes with circadian orthologs, organism-specific biosystem; Formation of tubulin folding intermediates by CCT/TriC, organism-specific biosystem;
Function : G-protein coupled peptide receptor activity; melanocortin receptor activity; melanocyte-stimulating hormone receptor activity; protein binding; receptor activity;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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