Native Human MMP11


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Native Human MMP11

MMP11 Related Products

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Cat.No. : MMP11-27648TH
Product Overview : Full length Human MMP11 protein (purified from stimulated human fibroblasts) and supplied as a mixture of zymogen and processed (cleaved)forms.
Description : Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMPs, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.
Tissue specificity : Specifically expressed in stromal cells of breast carcinomas.
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 50% Glycerol, 0.02% Brij 35, 5mM Calcium chloride, 100mM Sodium chloride, 10mM Tris HCl, pH 7.4
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the peptidase M10A family.Contains 4 hemopexin-like domains.
Gene Name : MMP11 matrix metallopeptidase 11 (stromelysin 3) [ Homo sapiens ]
Official Symbol : MMP11
Synonyms : MMP11; matrix metallopeptidase 11 (stromelysin 3); matrix metalloproteinase 11 (stromelysin 3) , STMY3; stromelysin-3;
Gene ID : 4320
mRNA Refseq : NM_005940
Protein Refseq : NP_005931
MIM : 185261
Uniprot ID : P24347
Chromosome Location : 22q11.23
Pathway : Matrix Metalloproteinases, organism-specific biosystem;
Function : calcium ion binding; metalloendopeptidase activity; peptidase activity; zinc ion binding;

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