|Product Overview :
||Full length Human MMP2 protein (purified from human fibroblast cell culture media).
||Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene.
|Tissue specificity :
||Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate.
|Biological activity :
||Degrades denatured Collagen (gelatin), and a range of extracellular matrix components in-vivo.
|Storage buffer :
||Preservative: NoneConstituents: 50% Glycerol, PBS, 250mM Sodium chloride, pH 7.4
||Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
|Sequence Similarities :
||Belongs to the peptidase M10A family.Contains 3 fibronectin type-II domains.Contains 4 hemopexin-like domains.