Recombinant Human Matrix Metallopeptidase 1
Cat.No. : | MMP1-407H |
- Specification
- Gene Information
- Related Products
Cat. No. : | MMP1-407H |
Description : | Matrix metallopeptidase 1 (interstitial collagenase), also known as MMP1 is an enzyme involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP"s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP-1 is the only enzyme able to initiate breakdown of the interstitial collagens, collagen type 1, collagen type 2, and collagen type 3. MMP-1 plays an important role in diverse physiologic processes such as development, tissue morphogenesis, and wound repair. Expression of MMP-1 is a prognostic marker for hematogenous metastasis of colorectal cancer. |
Source : | Mammalian cells |
State Of Matter : | Solution. |
Purity : | >95% by SDS Page and analyzed by silver stain. |
Endotoxin : | <1.0 EU/µg as determined by the LAL method. |
Molecular Weight : | The predicted molecular weight of Recombinant Human MMP-1 is Mr 52-55 kDa. |
Storage : | -20°C to -70°C. |
Gene Name : | MMP1 matrix metallopeptidase 1 (interstitial collagenase) [ Homo sapiens ] |
Synonyms : | MMP1; matrix metallopeptidase 1 (interstitial collagenase); CLG; CLGN; matrix metalloproteinase 1; fibroblast collagenase; matrix metalloprotease 1; EC 3.4.24.7; Interstitial collagenase; Matrix metalloproteinase-1; MMP-1; Fibroblast collagenase; 22 kDa interstitial collagenase; 27 kDa interstitial collagenase |
Gene ID : | 4312 |
mRNA Refseq : | NM_001145938 |
Protein Refseq : | NP_001139410 |
MIM : | 120353 |
UniProt ID : | P03956 |
Chromosome Location : | 11q21-q22 |
Pathway : | Bladder cancer; PPAR signaling pathway; Pathways in cancer; Diabetes pathways; Hemostasis; Signaling in Immune system |
Function : | calcium ion binding; metalloendopeptidase activity; peptidase activity; zinc ion binding |
Products Types
◆ Recombinant Protein | ||
MMP1-2535H | Recombinant Human MMP1 protein(111-290 aa), N-MBP & C-His-tagged | +Inquiry |
MMP1-799H | Recombinant Human MMP1 Protein, His-tagged | +Inquiry |
MMP1-238H | Recombinant Active Human MMP1 Protein, His-tagged(C-ter) | +Inquiry |
MMP1-5413H | Recombinant Human MMP1 Protein, GST-tagged | +Inquiry |
MMP1-2536H | Recombinant Human MMP1 protein(20-469 aa), N-MBP & C-His-tagged | +Inquiry |
◆ Native Protein | ||
MMP1-45H | Native Human MMP-1 | +Inquiry |
◆ Lysates | ||
MMP1-2884HCL | Recombinant Human MMP1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionMMP1 is involved in the remodeling of tissue during wound healing by facilitating the breakdown of damaged extracellular matrix components.
Inhibiting MMP1 activity is being explored as a potential therapeutic strategy to impede cancer progression and metastasis.
MMP1 plays a key role in tissue remodeling by degrading collagen, a major component of the extracellular matrix, which is essential for processes like wound healing.
MMP1 overexpression is associated with various diseases, including rheumatoid arthritis, atherosclerosis, and certain types of cancer.
High MMP1 levels have been correlated with poor prognosis in certain cancer types, making it a potential biomarker for predicting disease outcomes.
Customer Reviews (3)
Write a reviewThe manufacturer can offer technical support and expertise to guide researchers through the experimental process.
The manufacturer can play a vital role in supporting and optimizing the research process.
This guarantees that the protein is reliable, consistent, and suitable for experiments, reducing variability and enhancing the reproducibility of findings.
Ask a Question for All MMP1 Products
Required fields are marked with *
My Review for All MMP1 Products
Required fields are marked with *
Inquiry Basket