Recombinant Human MSH2 protein, GST-tagged
Cat.No. : | MSH2-28175TH |
Product Overview : | Recombinant Human MSH2(1 a.a. - 934 a.a.) fused with GST tag at N-terminal was expressed in Wheat Germ. |
- Specification
- Gene Information
- Related Products
Description : | This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Form : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Molecular Mass : | 131.1 kDa |
AA Sequence : | MAVQPKETLQLESAAEVGFVRFFQG MPEKPTTTVRLFDRGDFYTAHGEDA LLAAREVFKTQGVIKYMGPAGAKNL QSVVLSKMNFESFVKDLLLVRQYRV EVYKNRAGNKASKENDWYLAYKASP GNLSQFEDILFGNNDMSASIGVVGV KMSAVDGQRQVGVGYVDSIQRKLGL CEFPDNDQFSNLEALLIQIGPKECV LPGGETAGDMGKLRQIIQRGGILIT ERKKADFSTKDIYQDLNRLLKGKKG EQMNS |
Applications : | Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Gene Name : | MSH2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) [ Homo sapiens ] |
Official Symbol : | MSH2 |
Synonyms : | MSH2; mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli); COCA1, mutS (E. coli) homolog 2 (colon cancer, nonpolyposis type 1); DNA mismatch repair protein Msh2; HNPCC; HNPCC1; hMSH2; FCC1; COCA1; LCFS2; |
Gene ID : | 4436 |
mRNA Refseq : | NM_000251 |
Protein Refseq : | NP_000242 |
MIM : | 609309 |
UniProt ID : | P43246 |
Chromosome Location : | 2p21 |
Pathway : | BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem; Colorectal cancer, organism-specific biosystem; Colorectal cancer, conserved biosystem; Direct p53 effectors, organism-specific biosystem; Mismatch repair, organism-specific biosystem; Mismatch repair, conserved biosystem; Pathways in cancer, organism-specific biosystem; |
Function : | contributes_to ADP binding; contributes_to ATP binding; contributes_to ATPase activity; DNA binding; DNA-dependent ATPase activity; contributes_to MutLalpha complex binding; Y-form DNA binding; centromeric DNA binding; damaged DNA binding; contributes_to dinucleotide insertion or deletion binding; contributes_to dinucleotide repeat insertion binding; double-strand/single-strand DNA junction binding; contributes_to double-stranded DNA binding; enzyme binding; contributes_to four-way junction DNA binding; contributes_to guanine/thymine mispair binding |
Products Types
◆ Recombinant Protein | ||
MSH2-5739M | Recombinant Mouse MSH2 Protein, His (Fc)-Avi-tagged | +Inquiry |
MSH2-1138P | Recombinant Pig MSH2 Protein, His-tagged | +Inquiry |
MSH2-2456H | Recombinant Human MSH2 Protein, His-tagged | +Inquiry |
MSH2-3446R | Recombinant Rat MSH2 Protein, His (Fc)-Avi-tagged | +Inquiry |
MSH2-1137H | Recombinant Human MSH2 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
MSH2-4120HCL | Recombinant Human MSH2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (0)
Ask a questionAsk a Question for All MSH2 Products
Required fields are marked with *
My Review for All MSH2 Products
Required fields are marked with *
0
Inquiry Basket