| Description : |
This gene encodes a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain. The protein is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in MYH9 are the cause of non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. |
| Conjugation : |
HIS |
| Source : |
E. coli |
| Tissue specificity : |
In the kidney, expressed in the glomeruli. Also expressed in leukocytes. |
| Form : |
Lyophilised:Reconstitute with 51 μl aqua dest. |
| Storage buffer : |
Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5 |
| Storage : |
Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
| Sequences of amino acids : |
AEKQKRDLGEELEALKTELEDTLDS TAAQQELRSKREQEV NILKKTLEEEAKTHEAQIQEMRQKH SQAVEELAEQLEQ TKRVKANLEKAKQTLENERGELANE VKVLLQGKGDSEHKR KKVEAQLQELQVKFNEGERVRTELA DKVTKLQVELDNV TGLLSQSDSKSSKLTKDFSALESQL QDTQELLQEENRQ KLSLSTKLKQVEDEKNSFREQLEEE EEAKHNLEKQIATLH AQVADMKKKMEDSVGCLETAEEVKR KLQKDLEGLSQRH EEKVAAYDKLEKTKTRLQQELDDLL VDLDHQRQSACNL EKKQKKFDQLLAEEKTISAKYAEER DRAEAEAREKETKAL SLARALEEAMEQKAELERLNKQFRT EMEDLMSSKDDVG KSVHELEKSKRALEQQVEEMKTQLE ELEDELQATEDAKLRLEVNLQAMKA QFERDLQGRDEQSEEKKKQLVRQVR EME AELEDERKQRSMAVAARKKLEMDLK DLEAHIDSANKNR DEAIKQLRKLQAQMKDCMRELDDTR ASREEILAQAKENEK KLKSMEAEMIQLQEELAAAERAKRQ AQQERDELADEIA NSSGKGALALEEKRRLEARIAQLEE ELEEEQGNTELIN DRLKKANLQIDQINTDLNLERSHAQ KNENARQQLERQNKE LKVKLQEMEGTVKSKYKASITALEA KIAQLEEQLDNET KERQAACKQVRRTEKKLKDVLLQVD DERRNAEQYKDQA DKASTRLKQLKRQLEEAEEEAQRAN ASRRKLQRELEDATE TADAMNREVSSLKNKLRRGDLPFVV PRRMARKGAGDGS DEEVDGKADGAEAKPAE |
| Sequence Similarities : |
Contains 1 IQ domain.Contains 1 myosin head-like domain. |
