Recombinant Human NDN

• Cat.No.: NDN-30373TH
• Product Overview: Recombinant full length Human Necdin with N terminal proprietary tag, 61.38kDa.

Specification

• Description: This intronless gene is located in the Prader-Willi syndrome deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene may suppress growth in postmitotic neurons.
• Protein length: 321 amino acids
• Molecular Weight: 61.380kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Almost ubiquitous. Detected in fetal brain, lung, liver and kidney; in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Not detected in peripheral blood leuko
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MSEQSKDLSDPNFAAEAPNSEVHSSPGVSEGVPPSATLAE PQSPPLGPTAAPQAAPPPQAPNDEGDPKALQQAAEEGRAH QAPSAAQPGPAPPAPAQLVQKAHELMWYVLVKDQKKMIIW FPDMVKDVIGSYKKWCRSILRRTSLILARVFGLHLRLTSL HTMEFALVKALEPEELDRVALSNRMPMTGLLLMILSLIYV KGRGARESAVWNVLRILGLRPWKKHSTFGDVRKLITEEFV QMNYLKYQRVPYVEPPEYEFFWGSRASREITKMQIMEFLA RVFKKDPQAWPSRYREALEEARALREANPTAHYPRSSVSE D
• Sequence Similarities: Contains 1 MAGE domain.

Gene Information

• Gene Name: NDN necdin homolog (mouse) [ Homo sapiens ]
• Official Symbol: NDN
• Synonyms: NDN; necdin homolog (mouse); necdin (mouse) homolog; necdin; HsT16328; PWCR
• Gene ID: 4692
• mRNA Refseq: NM_002487
• Protein Refseq: NP_002478
• MIM: 602117
• Uniprot ID: Q99608
• Chromosome Location: 15q11-q12
• Pathway: Adipogenesis, organism-specific biosystem; p75(NTR)-mediated signaling, organism-specific biosystem
• Function: DNA binding; gamma-tubulin binding