"NME1" Related Products

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Recombinant Human NME1

Cat.No.: NME1-28097TH
Product Overview: Recombinant full length Human NM23A; amino acids 1-152 , 17.1kDa.
Description: This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of A (encoded by this gene) and B (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.
Source: E. coli
Tissue specificity: Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to t
Form: Liquid
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 7.5
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids: MANCERTFIA IKPDGVQRGL VGEIIKRFEQ KGFRLVGLKF MQASEDLLKE HYVDLKDRPF FAGLVKYMHS GPVVAMVWEG LNVVKTGRVM LGETNPADSK PGTIRGDFCI QVGRNIIHGS DSVESAEKEI GLWFHPEELV DYTSCAQNWI YE
Sequence Similarities: Belongs to the NDK family.
Gene Name: NME1 non-metastatic cells 1, protein (NM23A) expressed in [ Homo sapiens ]
Official Symbol: NME1
Synonyms: NME1; non-metastatic cells 1, protein (NM23A) expressed in; nucleoside diphosphate kinase A; NM23; NM23 H1;
Gene ID: 4830
mRNA Refseq: NM_000269
Protein Refseq: NP_000260
MIM: 156490
Uniprot ID: P15531
Chromosome Location: 17q21.33
Pathway: Arf6 downstream pathway, organism-specific biosystem; Arf6 trafficking events, organism-specific biosystem; E-cadherin signaling in the nascent adherens junction, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem;
Function: ATP binding; GTP binding; deoxyribonuclease activity; gamma-tubulin binding; identical protein binding;

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