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Recombinant Human PABPC1, His-tagged

Cat.No. : PABPC1-30620TH
Product Overview : Recombinant fragment, corresponding to amino acids 96-636 of Human PABP with N terminal His tag; Predicted MWt 61 kDa.
  • Specification
  • Gene Information
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Description : This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3 poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.
Conjugation : HIS
Source : E. coli
Form : Lyophilised:Reconstitute with 149 μl aqua dest.
Storage buffer : Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
Storage : Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : SGVGNIFIKNLDKSIDNKALYDTFS AFGNILSCKVVCDEN GSKGYGFVHFETQEAAERAIEKMNG MLLNDRKVFVGRF KSRKEREAELGARAKEFTNVYIKNF GEDMDDERLKDLF GKFGPALSVKVMTDESGKSKGFGFV SFERHEDAQKAVD EMNGKELNGKQIYVGRAQKKVERQT ELKRKFEQMKQDRIT RYQGVNLYVKNLDDGIDDERLRKEF SPFGTITSAKVMM EGGRSKGFGFVCFSSPEEATKAVTE MNGRIVATKPLYV ALAQRKEERQAHLTNQYMQRMASVR AVPNPVINPYQPA PPSGYFMAAIPQTQNRAAYYPPSQI AQLRPSPRWTAQGAR PHPFQNMPGAIRPAAPRPPFSTMRP ASSQVPRVMSTQR VANTSTQTMGPRPAAAAAAATPAVR TVPQYKYAAGVRN PQQHLNAQPQVTMQQPAVHVQGQEP LTASMLASAPPQE QKQMLGERLFPLIQAMHPTLAGKIT GMLLEIDNSELLHMLESPESLRSKV DEAVAVLQAHQAKEAAQKAVNSATG VPT V
Gene Name : PABPC1 poly(A) binding protein, cytoplasmic 1 [ Homo sapiens ]
Official Symbol : PABPC1
Synonyms : PABPC1; poly(A) binding protein, cytoplasmic 1; PAB1, PABPC2, poly(A) binding protein, cytoplasmic 2; polyadenylate-binding protein 1; PABP1; PABPL1;
Gene ID : 26986
mRNA Refseq : NM_002568
Protein Refseq : NP_002559
MIM : 604679
Uniprot ID : P11940
Chromosome Location : 8q22.2-q23
Pathway : Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem; Cap-dependent Translation Initiation, organism-specific biosystem; Deadenylation of mRNA, organism-specific biosystem; Deadenylation-dependent mRNA decay, organism-specific biosystem; Destabilization of mRNA by AUF1 (hnRNP D0), organism-specific biosystem;
Function : RNA binding; nucleotide binding; poly(A) RNA binding; poly(A) RNA binding; protein C-terminus binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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