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Recombinant Mouse Tnfsf8

Cat. No.: Tnfsf8-1714M
Description: The CD30 ligand is a type II transmembrane glycoprotein of the tumor necrosis factor ligand superfamily. CD30L is expressed on the cell surface of activated T cells, B cells, and monocytes. Recombinant CD30L has been shown to co-stimulate T cells and to act as a mitogen for Hodgkin"s disease derived cell lines. The receptor for CD30L, CD30/ TNFRSF8/CD153, is a type I cytokine receptor that is highly expressed by activated T cells, Hodgkin and Reed- Sternberg (H-RS) cells, and anaplastic large cell lymphoma cells. CD30 ligation by CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation and cell death by apoptosis.
Molecular Weight: The predicted molecular weight of Recombinant Mouse CD30L is Mr 22 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 30-45 kDa.
Source: NSO Cells.
State Of Matter: Lyophilized.
Purity: >95% by SDS Page and analyzed by silver stain.
Endotoxin: <0.1 ng per 1 µg as determined by the LAL method.
Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name: Tnfsf8 tumor necrosis factor (ligand) superfamily, member 8 [ Mus musculus ]
Synonyms: Tnfsf8; tumor necrosis factor (ligand) superfamily, member 8; CD153; Cd30l; CD30LG; OTTMUSP00000000340
Gene ID: 21949
mRNA Refseq: NM_009403
Protein Refseq: NP_033429
UniProt ID: P32972
Chromosome Location: 4 C1; 4 32.2 cM
Pathway: Cytokine-cytokine receptor interaction
Function: cytokine activity; tumor necrosis factor receptor binding

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