Native Human PLAT
Cat.No. : | PLAT-30920TH |
Product Overview : | Full length Human TPA Tissue Plasminogen Activator labelled at the active site with ATA-Phe-Pro-Arg-CMK, MWt 70kDa. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. |
Tissue specificity : | Synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk. |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 0.4M HEPES, 0.1M Sodium chloride, pH 7.4 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the peptidase S1 family.Contains 1 EGF-like domain.Contains 1 fibronectin type-I domain.Contains 2 kringle domains.Contains 1 peptidase S1 domain. |
Gene Name : | PLAT plasminogen activator, tissue [ Homo sapiens ] |
Official Symbol : | PLAT |
Synonyms : | PLAT; plasminogen activator, tissue; tissue-type plasminogen activator; |
Gene ID : | 5327 |
mRNA Refseq : | NM_000930 |
Protein Refseq : | NP_000921 |
MIM : | 173370 |
Uniprot ID : | P00750 |
Chromosome Location : | 8p11.21 |
Pathway : | Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Dissolution of Fibrin Clot, organism-specific biosystem; |
Function : | peptidase activity; protein binding; serine-type endopeptidase activity; serine-type endopeptidase activity; |
Products Types
◆ Recombinant Protein | ||
PLAT-5461H | Recombinant Human Plasminogen Activator, Tissue | +Inquiry |
PLAT-4154R | Recombinant Rat PLAT Protein, His (Fc)-Avi-tagged | +Inquiry |
Plat-5463M | Recombinant Mouse Plasminogen Activator, Tissue | +Inquiry |
PLAT-1870H | Recombinant Human PLAT Protein, MYC/DDK-tagged | +Inquiry |
PLAT-8525H | Recombinant Human PLAT protein(Tyr37-Arg310), hFc-tagged | +Inquiry |
◆ Native Protein | ||
PLAT-29690TH | Native Human Human SERPINE1 | +Inquiry |
PLAT-30946TH | Native Human PLAT | +Inquiry |
◆ Lysates | ||
PLAT-1498MCL | Recombinant Mouse PLAT cell lysate | +Inquiry |
PLAT-2833HCL | Recombinant Human PLAT cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0701 | PLAT (Human) Chromogenic Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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