Native Human PLAT

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Native Human PLAT

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Cat.No. : PLAT-30920TH
Product Overview : Full length Human TPA Tissue Plasminogen Activator labelled at the active site with ATA-Phe-Pro-Arg-CMK, MWt 70kDa.
Description : This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
Tissue specificity : Synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk.
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 0.4M HEPES, 0.1M Sodium chloride, pH 7.4
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the peptidase S1 family.Contains 1 EGF-like domain.Contains 1 fibronectin type-I domain.Contains 2 kringle domains.Contains 1 peptidase S1 domain.
Gene Name : PLAT plasminogen activator, tissue [ Homo sapiens ]
Official Symbol : PLAT
Synonyms : PLAT; plasminogen activator, tissue; tissue-type plasminogen activator;
Gene ID : 5327
mRNA Refseq : NM_000930
Protein Refseq : NP_000921
MIM : 173370
Uniprot ID : P00750
Chromosome Location : 8p11.21
Pathway : Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Dissolution of Fibrin Clot, organism-specific biosystem;
Function : peptidase activity; protein binding; serine-type endopeptidase activity; serine-type endopeptidase activity;

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