Recombinant Human POT1


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Recombinant Human POT1

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Cat.No. : POT1-27935TH
Product Overview : Recombinant fragment corresponding to amino acids 1-95 of Human POT1 with a propreitary tag; predicted mwt: 36.08 kDa.
Description : This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.
Protein length : 95 amino acids
Molecular Weight : 36.080kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Ubiquitous.
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.79% Tris HCl, 0.31% Glutathione
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the telombin family.
Gene Name : POT1 protection of telomeres 1 homolog (S. pombe) [ Homo sapiens ]
Official Symbol : POT1
Synonyms : POT1; protection of telomeres 1 homolog (S. pombe); protection of telomeres protein 1; DKFZp586D211; hPot1;
Gene ID : 25913
mRNA Refseq : NM_001042594
Protein Refseq : NP_001036059
MIM : 606478
Uniprot ID : Q9NUX5
Chromosome Location : 7q31.33
Pathway : Chromosome Maintenance, organism-specific biosystem; Meiosis, organism-specific biosystem; Meiotic Synapsis, organism-specific biosystem; Packaging Of Telomere Ends, organism-specific biosystem; Regulation of Telomerase, organism-specific biosystem;
Function : DEAD/H-box RNA helicase binding; DNA binding; protein binding; single-stranded telomeric DNA binding; single-stranded telomeric DNA binding;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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