| Description : |
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. |
| Protein length : |
601 amino acids |
| Molecular Weight : |
92.180kDa inclusive of tags |
| Source : |
Wheat germ |
| Form : |
Liquid |
| Purity : |
Proprietary Purification |
| Storage buffer : |
pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
| Storage : |
Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
| Sequences of amino acids : |
MAGASELGTGPGAAGGDGDDSLYPIAVLIDELRNEDVQLR LNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLA LAEQLGNFTGLVGGPDFAHCLLPPLENLATVEETVVRDKA VESLRQISQEHTPVALEAYFVPLVKRLASGDWFTSRTSAC GLFSVCYPRASNAVKAEIRQQFRSLCSDDTPMVRRAAASK LGEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEAC VSIAQLLSQDDLETLVMPTLRQAAEDKSWRVRYMVADRFS ELQKAMGPKITLNDLIPAFQNLLKDCEAEVRAAAAHKVKE LGENLPIEDRETIIMNQILPYIKELVSDTNQHVKSALASV IMGLSTILGKENTIEHLLPLFLAQLKDECPDVRLNIISNL DCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMP LLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMK LVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINAL SEACGQEITTKQMLPIVLKMAGDQVANVRFNVAKSLQKIG PILDTNALQGEVKPVLQKLGQDEDMDVKYFAQEAISVLAL A |
| Sequence Similarities : |
Belongs to the phosphatase 2A regulatory subunit A family.Contains 15 HEAT repeats. |
