Native Human PROS1


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Native Human PROS1

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Cat.No. : PROS1-31218TH
Product Overview : Purified full length native human Protein S, isolated from fresh frozen plasma, is a single chain protein containing 10 gla residues in the NH2-terminal domain and 4 epidermal growth factor (EGF) domains, MW 69kDa.Post translational modifications: one bet
Description : This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3.
Tissue specificity : Plasma.
Form : Liquid
Purity : Immunogen affinity purified
Storage buffer : Preservative: NoneConstituents: 50% Glycerol
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequence Similarities : Contains 4 EGF-like domains.Contains 1 Gla (gamma-carboxy-glutamate) domain.Contains 2 laminin G-like domains.
Gene Name : PROS1 protein S (alpha) [ Homo sapiens ]
Official Symbol : PROS1
Synonyms : PROS1; protein S (alpha); PROS; vitamin K-dependent protein S;
Gene ID : 5627
mRNA Refseq : NM_000313
Protein Refseq : NP_000304
MIM : 176880
Uniprot ID : P07225
Chromosome Location : 3p11-q11.2
Pathway : Cell surface interactions at the vascular wall, organism-specific biosystem; Common Pathway, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem;
Function : calcium ion binding; endopeptidase inhibitor activity;

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