Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Active Recombinant Human PTPN11 protein, GST-tagged

Cat.No. : PTPN11-31402TH
Product Overview : Recombinant Human PTPN11(224–529 aa) fused with GST tag at N-terminal was expressed in E. coli.
Unit
Price
Qty
  • Specification
  • Gene Information
  • Related Products
Description : Mammalian PTPases can be subdivided into 1 of 2 broad categories: transmembrane receptor PTPases and intracellular PTPases. PTPN11 is one of the 2 closely related mammalian intracellular PTPases whose sequences encode 2 tandem SRC homology 2 (SH2) domains that are located at the amino-terminal side of a single PTPase catalytic domain. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration.
Source : E. coli
Species : Human
Tag : GST
Form : 25 mM Tris-HCl, pH 8.0, 75 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, 10 mM glutathione.
Bio-activity : 10 U/µg
Molecular Mass : 62 kDa
AA Sequence : MSPILGYWKIKGLVQPTRLLLEYLE EKYEEHLYERDEGDKWRNKKFELGL EFPNLPYYIDGDVKLTQSMAIIRYI ADKHNMLGGCPKERAEISMLEGAVL DIRYGVSRIAYSKDFETLKVDFLSK LPEMLKMFEDRLCHKTYLNGDHVTH PDFMLYDALDVVLYMDPMCLDAFPK LVCFKKRIEAIPQIDKYLKSSKYIA WPLQGWQATFGGGDHPPKSDLVPRG SASAEIESRVRELSKLAETTDKVKQ GFWEEFETLQQQECKLLYSRKEGQR QENKNKNRYKNILPFDHTRVVLHDG DPNEPVSDYINANIIMPEFETKCNN SKPKKSYIATQGCLQNTVNDFWRMV FQENSRVIVMTTKEVERGKSKCVKY WPDEYALKEYGVMRVRNVKESAAHD YTLRELKLSKVGQGNTERTVWQYHF RTWPDHGVPSDPGGVLDFLEEVHHK QESIMDAGPVVVHCSAGIGRTGTFI VIDILIDIIREKGVDCDIDVPKTIQ MVRSQRSGMVQTEAQYRFIYMAVQH YIETLQRRILE
Purity : > 90%
Unit Definition : One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30 centigrade.
Applications : Useful for the study of enzyme kinetics and regulation, to dephosphorylate target substrates and for screening inhibitors.
Storage : >12 months at -80 centigrade. Avoid freeze/thaw cycles.
Concentration : 0.73 mg/ml
Publication :
Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor (2017)
Gene Name : PTPN11 protein tyrosine phosphatase, non-receptor type 11 [ Homo sapiens ]
Official Symbol : PTPN11
Synonyms : PTPN11; protein tyrosine phosphatase, non-receptor type 11; Noonan syndrome 1 , NS1; tyrosine-protein phosphatase non-receptor type 11; BPTP3; PTP2C; SH PTP2; SHP 2; SHP2; PTP-2C; protein tyrosine phosphatase-2; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C; CFC; NS1; PTP-1D; SH-PTP2; SH-PTP3; MGC14433;
Gene ID : 5781
mRNA Refseq : NM_002834
Protein Refseq : NP_002825
MIM : 176876
UniProt ID : Q06124
Chromosome Location : 12q24.1
Pathway : Adaptive Immune System, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Axon guidance, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; CTLA4 inhibitory signaling, organism-specific biosystem;
Function : hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity; non-membrane spanning protein tyrosine phosphatase activity; protein binding; protein tyrosine phosphatase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there genetic tests available to detect PTPN11 mutations? 12/17/2022

Yes, genetic testing can identify mutations in the PTPN11 gene, providing valuable information for diagnosis and treatment planning.

How does PTPN11 impact cell signaling pathways? 06/21/2022

PTPN11 is involved in various signaling pathways, including the RAS-MAPK pathway, and its mutations can dysregulate these pathways, leading to abnormal cell signaling.

Is PTPN11 involved in normal cellular functions? 02/20/2022

Yes, PTPN11 plays a crucial role in normal cellular functions by regulating the activity of proteins through dephosphorylation.

Can PTPN11 be used as a biomarker for certain diseases? 10/27/2020

Yes, the presence of PTPN11 mutations can serve as a biomarker for specific cancers and developmental disorders.

How is PTPN11 involved in developmental disorders? 02/04/2018

Mutations in PTPN11 can lead to developmental disorders, including Noonan syndrome and LEOPARD syndrome, affecting growth and development.

Customer Reviews (3)

Write a review
Reviews
08/01/2020

    Their technical expertise and knowledge of the PTPN11 protein are invaluable resources.

    05/18/2016

      This reliability reduces experimental variability and enhances the accuracy of data interpretation.

      04/11/2016

        the manufacturer's commitment to continuous innovation and development of new tools and technologies ensures that I have access to the latest advancements in PTPN11 protein research.

        Ask a Question for All PTPN11 Products

        Required fields are marked with *

        My Review for All PTPN11 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends