"PTPN11" Related Products

Expand
Expand

Recombinant Human PTPN11 protein, GST-tagged

Cat.No. : PTPN11-31402TH
Product Overview : Recombinant Human PTPN11(224–529 aa) fused with GST tag at N-terminal was expressed in E. coli.
Description : Mammalian PTPases can be subdivided into 1 of 2 broad categories: transmembrane receptor PTPases and intracellular PTPases. PTPN11 is one of the 2 closely related mammalian intracellular PTPases whose sequences encode 2 tandem SRC homology 2 (SH2) domains that are located at the amino-terminal side of a single PTPase catalytic domain. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration.
Source : E. coli
Species : Human
Tag : GST
Form : 25 mM Tris-HCl, pH 8.0, 75 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, 10 mM glutathione.
Bio-activity : 10 U/µg
Molecular Mass : 62 kDa
AA Sequence : MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGLEFPNLPYYIDGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGAVLDIRYGVSRIAYSKDFETLKVDFLSKLPEMLKMFEDRLCHKTYLNGDHVTHPDFMLYDALDVVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYIAWPLQGWQATFGGGDHPPKSDLVPRGSASAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRILE
Purity : > 90%
Unit Definition : One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30 centigrade.
Applications : Useful for the study of enzyme kinetics and regulation, to dephosphorylate target substrates and for screening inhibitors.
Storage : >12 months at -80 centigrade. Avoid freeze/thaw cycles.
Concentration : 0.73 mg/ml
Figure :

Gene Name : PTPN11 protein tyrosine phosphatase, non-receptor type 11 [ Homo sapiens ]
Official Symbol : PTPN11
Synonyms : PTPN11; protein tyrosine phosphatase, non-receptor type 11; Noonan syndrome 1 , NS1; tyrosine-protein phosphatase non-receptor type 11; BPTP3; PTP2C; SH PTP2; SHP 2; SHP2; PTP-2C; protein tyrosine phosphatase-2; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C; CFC; NS1; PTP-1D; SH-PTP2; SH-PTP3; MGC14433;
Gene ID : 5781
mRNA Refseq : NM_002834
Protein Refseq : NP_002825
MIM : 176876
UniProt ID : Q06124
Chromosome Location : 12q24.1
Pathway : Adaptive Immune System, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Axon guidance, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; CTLA4 inhibitory signaling, organism-specific biosystem;
Function : hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity; non-membrane spanning protein tyrosine phosphatase activity; protein binding; protein tyrosine phosphatase activity;

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.