Recombinant Rat Intercellular Adhesion Molecule 1

Cat. No.: Icam1-1793R
Description: Intercellular adhesion molecule-1 (ICAM-1) is one of an important cell adhesion molecules (CAMs) family transmembrane glycoprotein and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. ICAM-1 is a marker of endothelial dysfunction leading to damaging vascular disorders, in umbilical and placental vascular tissue of gestational pregnancies.
Molecular Weight: The predicted molecular weight of Recombinant Rat ICAM-1 is Mr 78 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 110-125 kDa.
Source: NSO Cells.
State Of Matter: Lyophilized.
Purity: >95% by SDS Page and analyzed by silver stain.
Endotoxin: <1.0 EU/µg as determined by the LAL method
Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name: Icam1 intercellular adhesion molecule 1 [ Rattus norvegicus ]
Synonyms: Icam1; intercellular adhesion molecule 1; CD54; ICAM; cell adhesion molecule; ligand for leukocyte adhesion molecule LFA-1
Gene ID: 25464
mRNA Refseq: NM_012967
Protein Refseq: NP_037099
UniProt ID: Q00238
Chromosome Location: 8q13
Pathway: Cell adhesion molecules (CAMs); Leukocyte transendothelial migration; Natural killer cell mediated cytotoxicity
Function: integrin binding; protein binding

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