Recombinant Rat Intercellular Adhesion Molecule 1
Cat.No. : | Icam1-1793R |
- Specification
- Gene Information
- Related Products
Cat. No. : | Icam1-1793R |
Description : | Intercellular adhesion molecule-1 (ICAM-1) is one of an important cell adhesion molecules (CAMs) family transmembrane glycoprotein and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. ICAM-1 is a marker of endothelial dysfunction leading to damaging vascular disorders, in umbilical and placental vascular tissue of gestational pregnancies. |
Molecular Weight : | The predicted molecular weight of Recombinant Rat ICAM-1 is Mr 78 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 110-125 kDa. |
Source : | Mammalian cells |
State Of Matter : | Lyophilized. |
Purity : | >95% by SDS Page and analyzed by silver stain. |
Endotoxin : | <1.0 EU/µg as determined by the LAL method |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. |
Gene Name : | Icam1 intercellular adhesion molecule 1 [ Rattus norvegicus ] |
Synonyms : | Icam1; intercellular adhesion molecule 1; CD54; ICAM; cell adhesion molecule; ligand for leukocyte adhesion molecule LFA-1 |
Gene ID : | 25464 |
mRNA Refseq : | NM_012967 |
Protein Refseq : | NP_037099 |
UniProt ID : | Q00238 |
Chromosome Location : | 8q13 |
Pathway : | Cell adhesion molecules (CAMs); Leukocyte transendothelial migration; Natural killer cell mediated cytotoxicity |
Function : | integrin binding; protein binding |
Products Types
◆ Recombinant Protein | ||
Icam1-3323M | Active Recombinant Mouse Icam1 protein(Met1-Asn485), His&hFc-tagged | +Inquiry |
Icam1-4322M | Recombinant Mouse Icam1 Protein | +Inquiry |
ICAM1-292H | Recombinant Human ICAM1 Protein, Fc-tagged | +Inquiry |
ICAM1-657H | Recombinant Human ICAM1 protein(Met1-Glu480) | +Inquiry |
ICAM1-2266R | Recombinant Rabbit ICAM1 Protein, His&SUMO-tagged | +Inquiry |
◆ Lysates | ||
ICAM1-2655HCL | Recombinant Human ICAM1 cell lysate | +Inquiry |
ICAM1-1970RCL | Recombinant Rat ICAM1 cell lysate | +Inquiry |
ICAM1-2487MCL | Recombinant Mouse ICAM1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, targeting ICAM1 is being explored as a potential therapeutic strategy for inflammatory diseases, with research focusing on developing ICAM1 inhibitors.
ICAM1 is upregulated during inflammation, promoting the adhesion of immune cells to the endothelium and facilitating their migration into inflamed tissues.
ICAM1 expression can be altered in cancer cells and is implicated in promoting cancer progression by facilitating tumor cell adhesion, invasion, and metastasis.
ICAM1 levels can be measured in blood or tissue samples, and elevated levels may serve as diagnostic markers for certain inflammatory diseases.
Elevated levels of ICAM1 in some diseases may serve as prognostic markers, indicating disease severity and potential outcomes.
Customer Reviews (3)
Write a reviewManufacturers may provide documentation of the protein's validation, which includes information about its purity, concentration, stability, and potential contaminants.
This can be particularly important in clinical trials to ensure accurate and reliable results.
If the need arises for larger quantities of ICAM1 protein during the later stages of clinical trials, the manufacturer can facilitate scale-up production processes to meet those requirements.
Ask a Question for All Icam1 Products
Required fields are marked with *
My Review for All Icam1 Products
Required fields are marked with *
Inquiry Basket