||Recombinant full length Human RHOC protein; amino acids 1-193, Predicted MWt 22kDa.
||This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
||>90% by SDS-PAGE
||Preservative: NoneConstituents: 40mM Sodium chloride, 25mM HEPES, 2mM DTT, 2mM Magnesium chloride, 0.01mM GDP, pH 7.2
||Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
||Belongs to the small GTPase superfamily. Rho family.