||Recombinant fragment, corresponding to amino acids 32-191 of Human RHOG with an N terminal His tag; MWt 19kDa.
||This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X.
||Lyophilised:Reconstitute with 104 μl aqua dest.
||Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
||Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
|Sequences of amino acids:
||YIPTVFDNYSAQSAVDGRTVNLNLWDTAGQEEYDRLRTLS YPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVP ILLVGTKKDLRAQPDTLRRLKEQGQAPITPQQGQALAK QIHAVRYLECSALQQDGVKEVFAEAVRAVLNPTPIKRG RSCILL
||Belongs to the small GTPase superfamily. Rho family.