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Recombinant Rat Interleukin 15

Cat. No.: Il15-231R
Description: Interleukin 15 (IL-15) is a novel cytokine that uses beta- and gamma-chain of IL-2R for signal transduction and is structurally similarity to IL-2. IL-15 is secreted by activated monocytes/macrophages following infection by virus. This cytokine induces cell proliferation of natural killer cells. This cytokine and interleukin 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other"s activity. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. IL-15 can recruit and activate T lymphocytes in the synovial membrane, thereby contributing to Rheumatoid arthritis pathogenesis.
Source: Sf 21 Insect Cells.
Molecular Weight: The predicted molecular weight of Recombinant Rat IL-15 is Mr 70 kDa.
State Of Matter: Lyophilized.
Purity: >95% by SDS Page and HPLC.
Endotoxin: <1.0 EU/µg.
Storage And Stability: The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Gene Name: Il15 interleukin 15 [ Rattus norvegicus ]
Synonyms: Il15; interleukin 15
Gene ID: 25670
mRNA Refseq: NM_013129
Protein Refseq: NP_037261
UniProt ID: P97604
Chromosome Location: 19q11
Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
Function: cytokine activity; molecular_function; protein binding

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