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Recombinant Mouse Interleukin 1 Receptor, Type II

Cat. No.: Il1r2-1754M
Description: Interleukin 1 receptor type II (IL1R2), also known as CD121b (Cluster of Differentiation 121b), is a transmembrane protein found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. It is a decoy receptor known for its ability to buffer IL-1 effects. IL-1RII is involved in the control of the proinflammatory state that takes place in the endometrium during the premenstrual and menstrual periods. IL-1RII can neutralize IL-1 beta and counteract its effect on endometrial stromal cells, and may provide a new clinical strategy for the treatment of endometriosis.
Molecular Weight: The predicted molecular weight of Recombinant Mouse IL-1 RII is Mr 64.7 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 70-80 kDa.
Source: Sf 21 Insect Cells.
State Of Matter: Lyophilized.
Purity: >95% by SDS Page and analyzed by silver stain.
Endotoxin: <1.0 EU/µg as determined by the LAL method.
Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name: Il1r2 interleukin 1 receptor, type II [ Mus musculus ]
Synonyms: Il1r2; interleukin 1 receptor, type II; CD121b; Il1r-2; IL-1 receptor beta chain
Gene ID: 16178
mRNA Refseq: NM_010555
Protein Refseq: NP_034685
UniProt ID: P27931
Chromosome Location: 1 B; 1 19.5 cM
Pathway: Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; MAPK signaling pathway
Function: interleukin-1 receptor activity; interleukin-1, Type II, blocking receptor activity; receptor activity

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