Recombinant Human RXRA

• Cat.No.: RXRA-28521TH
• Product Overview: Recombinant fragment, corresponding to amino acids 111-228 of Human Retinoid X Receptor alpha protein.

Specification

• Description: Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation.These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators.
• Source: E. coli
• Tissue specificity: Highly expressed in liver, also found in lung, kidney and heart.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 0.1M Sodium chloride, 5mM Beta mercaptoethanol, 20mM Tris HCl, pH 7.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequences of amino acids: MLGLNGVLKV PAHPSGNMAS FTKHICAICG DRSSGKHYGVYSCEGCKGFF KRTVRKDLTY TCRDNKDCLI DKRQRNRCQYCRYQKCLAMG MKREAVQEER QRGKDRNENE VESTSSANE
• Sequence Similarities: Belongs to the nuclear hormone receptor family. NR2 subfamily.Contains 1 nuclear receptor DNA-binding domain.

Gene Information

• Gene Name: RXRA retinoid X receptor, alpha [ Homo sapiens ]
• Official Symbol: RXRA
• Synonyms: RXRA; retinoid X receptor, alpha; retinoic acid receptor RXR-alpha; NR2B1
• Gene ID: 6256
• mRNA Refseq: NM_002957
• Protein Refseq: NP_002948
• MIM: 180245
• Uniprot ID: P19793
• Chromosome Location: 9q34
• Pathway: Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Adipogenesis, organism-specific biosystem; Bile secretion, organism-specific biosystem; Bile secretion, conserved biosystem
• Function: DNA binding; double-stranded DNA binding; enzyme binding; ligand-regulated transcription factor activity; metal ion binding