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Native Human SNCB

Cat.No.: SNCB-27206TH
Product Overview: Full length protein (Human)
Description: The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene.
Source: E. coli
Tissue specificity: Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
Form: Liquid
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 0.1M Sodium chloride, 20mM Tris HCl, 1mM Magnesium chloride, pH 7.5
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequences of amino acids: MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQGVASVAEKTK EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQEAAEEPLIEP LMEPEGESYE DPPQEEYQEY EPEA
Sequence Similarities: Belongs to the synuclein family.
Gene Name: SNCB synuclein, beta [ Homo sapiens ]
Official Symbol: SNCB
Synonyms: SNCB; synuclein, beta; beta-synuclein;
Gene ID: 6620
mRNA Refseq: NM_001001502
Protein Refseq: NP_001001502
MIM: 602569
Uniprot ID: Q16143
Chromosome Location: 5q35
Function: calcium ion binding; phospholipase inhibitor activity;

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