Native Human SNCB

• Cat.No.: SNCB-27206TH
• Product Overview: Full length protein (Human)

Specification

• Description: The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene.
• Source: E. coli
• Tissue specificity: Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 0.1M Sodium chloride, 20mM Tris HCl, 1mM Magnesium chloride, pH 7.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequences of amino acids: MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQGVASVAEKTK EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQEAAEEPLIEP LMEPEGESYE DPPQEEYQEY EPEA
• Sequence Similarities: Belongs to the synuclein family.

Gene Information

• Gene Name: SNCB synuclein, beta [ Homo sapiens ]
• Official Symbol: SNCB
• Synonyms: SNCB; synuclein, beta; beta-synuclein
• Gene ID: 6620
• mRNA Refseq: NM_001001502
• Protein Refseq: NP_001001502
• MIM: 602569
• Uniprot ID: Q16143
• Chromosome Location: 5q35
• Function: calcium ion binding; phospholipase inhibitor activity