Recombinant Human SNCB Protein, MYC/DDK-tagged

• Cat.No.: SNCB-245H
• Product Overview: Recombinant protein of human synuclein, beta (SNCB), transcript variant 1 with MYC/DDK at C-terminal was expressed in HEK293T.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
• Molecular Mass: 14.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at –80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: >50 ug/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: SNCB
• Official Symbol: SNCB synuclein beta [ Homo sapiens (human) ]
• Synonyms: SNCB; synuclein beta; beta-synuclein; I(2)-synuclein
• Gene ID: 6620
• mRNA Refseq: NM_003085
• Protein Refseq: NP_003076
• MIM: 602569
• UniProt ID: Q16143