Recombinant Human SOLH
Cat.No. : | SOLH-27401TH |
Product Overview : | Recombinant fragment of Human Calpain 15 with an N terminal proprietary tag; Predicted MWt 35.97 kDa. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a protein containing zinc-finger-like repeats and a calpain-like protease domain. The encoded protein may function as a transcription factor, RNA-binding protein, or in protein-protein interactions during visual system development. |
Protein length : | 94 amino acids |
Molecular Weight : | 35.970kDa inclusive of tags |
Source : | Wheat germ |
Tissue specificity : | Widely expressed with higher expression in brain. |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | HPKAYLHVQCDCTDSFNVVSTRGSL RTQDSVPPLHRQVLVILSQLEGNAG FSITHRLAHRKAAQAFLSDWTASKG THSPPLTPEVAGLHGPRPL |
Sequence Similarities : | Belongs to the peptidase C2 family.Contains 1 calpain catalytic domain.Contains 5 RanBP2-type zinc fingers. |
Gene Name : | SOLH small optic lobes homolog (Drosophila) [ Homo sapiens ] |
Official Symbol : | SOLH |
Synonyms : | SOLH; small optic lobes homolog (Drosophila); small optic lobes (Drosophila) homolog; calpain-15; CAPN15; |
Gene ID : | 6650 |
mRNA Refseq : | NM_005632 |
Protein Refseq : | NP_005623 |
MIM : | 603267 |
Uniprot ID : | O75808 |
Chromosome Location : | 16p13.3 |
Function : | calcium-dependent cysteine-type endopeptidase activity; cysteine-type peptidase activity; metal ion binding; peptidase activity; sequence-specific DNA binding transcription factor activity; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (17)
Ask a questionDysregulation of ARID4B has been implicated in various diseases and conditions. It has been found to be dysregulated in certain cancers, including breast, lung, and colorectal cancer, where it can contribute to tumor growth and metastasis. Additionally, ARID4B has been associated with neurodevelopmental disorders and intellectual disabilities, where mutations or alterations in ARID4B gene expression have been found in affected individuals.
ARID4B can interact with a range of proteins to carry out its functions. It has been found to interact with components of chromatin remodeling complexes, including histone deacetylases (HDACs) and the Sin3A co-repressor complex. ARID4B can also interact with other transcription factors and regulatory proteins to modulate gene expression.
Researchers commonly use techniques such as chromatin immunoprecipitation (ChIP) and sequencing (ChIP-seq), which allow them to identify genomic regions where ARID4B binds to DNA. They also use techniques like RNA-sequencing and gene expression analysis to study the effect of ARID4B on gene regulation. Additionally, cell culture experiments and animal models are utilized to investigate the functional roles of ARID4B in specific cellular processes and disease contexts.
Yes, ARID4B has been associated with several diseases and conditions. For example, mutations or deletions in the ARID4B gene have been found in individuals with Coffin-Siris syndrome, a rare genetic disorder characterized by developmental delays, intellectual disabilities, and distinctive physical features. Additionally, altered expression of ARID4B has been implicated in various types of cancers, including breast, lung, and pancreatic cancer, suggesting its involvement in tumor development and progression.
Yes, ARID4B consists of multiple functional domains. In addition to the ARID domain, it contains a C-terminal domain that is involved in protein-protein interactions. This domain allows ARID4B to interact with other proteins involved in chromatin remodeling and transcriptional regulation.
Yes, there have been reported genetic variations and mutations in the ARID4B gene. These variations can lead to altered expression or function of ARID4B and have been associated with certain diseases and conditions, such as intellectual disabilities and cancer.
ARID4B is expressed in multiple tissues, although the expression levels may vary across different tissues. It has been detected in various organs and cell types, including the brain, heart, liver, kidney, and immune cells. The expression of ARID4B may also be regulated during different stages of development or in response to specific signals or stimuli.
Yes, ARID4B is known to play a role in embryonic development. It is expressed in embryonic tissues and has been shown to be involved in regulating gene expression patterns critical for proper development of tissues and organs.
ARID4B has been proposed as a potential biomarker for certain diseases. For example, elevated expression of ARID4B has been associated with poor prognosis in breast cancer patients, suggesting its potential as a prognostic biomarker. However, further studies are needed to validate its clinical utility as a biomarker.
ARID4B contains several functional domains that contribute to its molecular functions. One of the key domains is the ARID (AT-rich interactive domain), which is responsible for DNA binding and recognition. ARID4B also contains regions that mediate protein-protein interactions, allowing it to interact with other proteins and complexes involved in chromatin remodeling and transcriptional regulation. Additionally, ARID4B has regions that may be involved in nuclear localization, transcriptional activation, or repression, but further research is needed to fully elucidate the functions of these domains.
Yes, ARID4B can bind to DNA. It contains a DNA-binding domain called an AT-rich interactive domain (ARID), which allows it to interact with specific DNA sequences and regulate gene expression.
Yes, ARID4B has been shown to play a role in embryonic development. Studies in mice have demonstrated that ARID4B is essential for the proper formation of tissues and organs during embryogenesis. Its expression is dynamically regulated during different stages of development, suggesting its involvement in controlling gene expression patterns that are crucial for embryonic development. Furthermore, mutations in ARID4B have been associated with developmental disorders, indicating its importance in normal embryonic development.
Yes, ARID4B has been found to interact with several other proteins in various cellular processes. It interacts with components of chromatin remodeling complexes, such as the SWI/SNF complex, which regulates gene expression through the modification of chromatin structure. ARID4B has also been shown to interact with transcription factors and co-activators, indicating its involvement in transcriptional regulation.
Currently, there are no specific drugs or therapies targeting ARID4B. However, as research progresses and our understanding of ARID4B's involvement in diseases deepens, it may become a potential target for therapeutic interventions. Developing targeted therapies for ARID4B will require further investigation into its precise functions, interactions, and mechanisms of action.
Yes, there are alternative splicing isoforms of ARID4B that have been identified. One isoform, called ARID4B-001, is the canonical isoform and is the most widely studied form of ARID4B. However, there are other isoforms, such as ARID4B-002, that have been detected in certain tissues or cell lines. These isoforms may have distinct functions or regulatory roles compared to the canonical isoform, although more research is needed to fully understand their specific functions.
Yes, ARID4B has been found to have both positive and negative regulatory effects on gene expression. It can act as a transcriptional co-activator, recruiting chromatin remodeling complexes to promote gene activation. On the other hand, ARID4B can also function as a transcriptional repressor by interacting with specific proteins or complexes that inhibit gene expression. The regulatory role of ARID4B depends on its interactions with other proteins and the specific context of the target gene.
Currently, there are no specific drugs or therapies targeting ARID4B. However, ongoing research on the role of ARID4B in diseases like cancer may lead to the development of targeted therapies in the future.
Customer Reviews (8)
Write a reviewIts high sensitivity enables the identification of low abundance targets, making it highly valuable in immunological research.
researchers have found ARID4B protein to be highly suitable for protein electron microscopy structure analysis.
Researchers who have utilized ARID4B protein praise its exceptional performance and reliability in their experiments.
It minimizes the risk of protein degradation and maximizes the effectiveness of the protein in various applications, such as cell signaling pathways or metabolic studies.
This stability is particularly advantageous for long-term studies or experiments involving extended incubation periods.
Its high level of consistency allows for precise measurements and accurate data interpretation, enhancing the reliability of my findings.
The manufacturer's deep understanding of the protein and its applications enables them to promptly and effectively address any issues that may arise during my trials.
ARID4B protein's ability to maintain structural integrity during imaging facilitates the detailed visualization of protein complexes and their interactions.
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