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Recombinant Human STK4

Cat.No.: STK4-30251TH
Product Overview: Recombinant full length MST1 protein (Human), was expressed by baculovirus in Sf9 cells using an N-terminal tag, MW ~83kDa.
Description: The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and its possible that this protein induces the chromatin condensation observed in this process.
Tissue specificity: Ubiquitously expressed.
Form: Liquid
Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.Contains 1 protein kinase domain.Contains 1 SARAH domain.
Gene Name: STK4 serine/threonine kinase 4 [ Homo sapiens ]
Official Symbol: STK4
Synonyms: STK4; serine/threonine kinase 4; serine/threonine-protein kinase 4; kinase responsive to stress 2; KRS2; mammalian sterile 20 like 1; MST1; yeast Ste20 like; YSK3;
Gene ID: 6789
mRNA Refseq: NM_006282
Protein Refseq: NP_006273
MIM: 604965
Uniprot ID: Q13043
Chromosome Location: 20q11.2-q13.2
Pathway: MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, conserved biosystem; Non-small cell lung cancer, organism-specific biosystem; Non-small cell lung cancer, conserved biosystem; Pathways in cancer, organism-specific biosystem;
Function: ATP binding; identical protein binding; magnesium ion binding; nucleotide binding; protein binding;

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