"PDE6C" Related Products


Recombinant Human PDE6C protein, GST-tagged

Cat.No.: PDE6C-444H
Product Overview: Recombinant Human PDE6C fused with GST tag at N-terminal was expressed in Insect cells.
Description: PDE6C or phosphodiesterase 6C, cGMP-specific, cone, alpha prime encodes the alpha-prime subunit of cone phosphodiesterase, which is composed of a homodimer of two alpha-prime subunits and 3 smaller proteins of 11, 13, and 15 kDa. PDE6C protein consists of 22 exons spanning approximately 48 kb of genomic DNA. The intron-exon structure of human PDE6C is very similar to that of rod PDE6B. A homologous genetic basis of the murine cpfl1 mutant and human achromatopsia linked to mutations in the PDE6C gene and mutations in PDE6C are associated with cone dystrophy type 4 (COD4).
Source: Insect cells
Species: Human
Tag: GST
Form: 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Molecular Mass: ~125 kDa
Purity: > 75%
Stability: 1 year at -70 centigrade from the date of shipment
Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.1 ug/uL
Gene Name: PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime [ Homo sapiens ]
Official Symbol: PDE6C
Synonyms: PDE6C; phosphodiesterase 6C, cGMP-specific, cone, alpha prime; cone cGMP-specific 3,5-cyclic phosphodiesterase subunit alpha; PDEA2; cGMP phosphodiesterase 6C; COD4;
Gene ID: 5146
mRNA Refseq: NM_006204
Protein Refseq: NP_006195
MIM: 600827
UniProt ID: P51160
Chromosome Location: 10q24
Pathway: Purine metabolism, organism-specific biosystem; Purine metabolism, conserved biosystem; Visual signal transduction: Cones, organism-specific biosystem;
Function: 3,5-cyclic-GMP phosphodiesterase activity; cGMP binding; hydrolase activity; metal ion binding; nucleotide binding; phosphoric diester hydrolase activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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