Recombinant Human STUB1

• Cat.No.: STUB1-30458TH
• Product Overview: Recombinant human STUB1 fragment, C-terminal.

Specification

• Description: STUB1, or CHIP, is a ubiquitin ligase/cochaperone that participates in protein quality control by targeting a broad range of chaperone protein substrates for degradation (Min et al.
• Source: E. coli
• Tissue specificity: Highly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney, liver and lung.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 50mM HEPES/KOH, 50mM Potassium chloride, 5mM DTT, pH 7.0
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Contains 3 TPR repeats.Contains 1 U-box domain.

Gene Information

• Gene Name: STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase [ Homo sapiens ]
• Official Symbol: STUB1
• Synonyms: STUB1; STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase; STIP1 homology and U box containing protein 1; E3 ubiquitin-protein ligase CHIP; CHIP; HSPABP2; NY CO 7; SDCCAG7; UBOX1
• Gene ID: 10273
• mRNA Refseq: NM_005861
• Protein Refseq: NP_005852
• MIM: 607207
• Uniprot ID: Q9UNE7
• Chromosome Location: 16p13.3
• Pathway: Adaptive Immune System, organism-specific biosystem; Alpha-synuclein signaling, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem
• Function: Hsp70 protein binding; Hsp90 protein binding; SMAD binding; TPR domain binding; enzyme binding