Recombinant Human TARDBP

• Cat.No.: TARDBP-30150TH
• Product Overview: Recombinant fragment (aa 1-259) human TARDBP protein.

Specification

• Description: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.
• Source: E. coli
• Tissue specificity: Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequence Similarities: Contains 2 RRM (RNA recognition motif) domains.

Gene Information

• Gene Name: TARDBP TAR DNA binding protein [ Homo sapiens ]
• Official Symbol: TARDBP
• Synonyms: TARDBP; TAR DNA binding protein; TAR DNA-binding protein 43; ALS10; TDP 43
• Gene ID: 23435
• mRNA Refseq: NM_007375
• Protein Refseq: NP_031401
• MIM: 605078
• Uniprot ID: Q13148
• Chromosome Location: 1p36.22
• Function: DNA binding; RNA binding; double-stranded DNA binding; mRNA 3-UTR binding; nucleotide binding