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Recombinant Human TARDBP

Cat.No.: TARDBP-30150TH
Product Overview: Recombinant fragment (aa 1-259) human TARDBP protein.
Description: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.
Source: E. coli
Tissue specificity: Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen.
Form: Liquid
Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequence Similarities: Contains 2 RRM (RNA recognition motif) domains.
Gene Name: TARDBP TAR DNA binding protein [ Homo sapiens ]
Official Symbol: TARDBP
Synonyms: TARDBP; TAR DNA binding protein; TAR DNA-binding protein 43; ALS10; TDP 43;
Gene ID: 23435
mRNA Refseq: NM_007375
Protein Refseq: NP_031401
MIM: 605078
Uniprot ID: Q13148
Chromosome Location: 1p36.22
Function: DNA binding; RNA binding; double-stranded DNA binding; mRNA 3-UTR binding; nucleotide binding;

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