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Native Human TG

Cat.No.: TG-31519TH
Product Overview: Full length native Human Thyroglobulin purified from Human thyroid tissue, amino acids 20-2768 , predicted MWt 303kDa.
Description: Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.
Protein length: 2749 amino acids
Molecular Weight: 303.000kDa
Tissue specificity: Thyroid gland specific.
Form: Lyophilised:Use of phosphate buffer, pH >7.0 containing 0.15M NaCl is recommended.
Purity: by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 0.02M Ammonium bicarbonate. May contain traces of buffer salts.
Storage: Store at +4°C.
Sequence Similarities: Belongs to the type-B carboxylesterase/lipase family.Contains 11 thyroglobulin type-1 domains.
Gene Name: TG thyroglobulin [ Homo sapiens ]
Official Symbol: TG
Synonyms: TG; thyroglobulin; AITD3; TGN;
Gene ID: 7038
mRNA Refseq: NM_003235
Protein Refseq: NP_003226
MIM: 188450
Uniprot ID: P01266
Chromosome Location: 8q24
Pathway: Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem;
Function: NOT carboxylesterase activity; chaperone binding; hormone activity; NOT neurexin family protein binding; NOT receptor activity;

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