Native Human TG
Cat.No. : | TG-31519TH |
Product Overview : | Full length native Human Thyroglobulin purified from Human thyroid tissue, amino acids 20-2768 , predicted MWt 303kDa. |
- Specification
- Gene Information
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Description : | Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. |
Protein length : | 2749 amino acids |
Molecular Weight : | 303.000kDa |
Tissue specificity : | Thyroid gland specific. |
Form : | Lyophilised:Use of phosphate buffer, pH >7.0 containing 0.15M NaCl is recommended. |
Purity : | by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 0.02M Ammonium bicarbonate. May contain traces of buffer salts. |
Storage : | Store at +4°C. |
Sequence Similarities : | Belongs to the type-B carboxylesterase/lipase family.Contains 11 thyroglobulin type-1 domains. |
Gene Name : | TG thyroglobulin [ Homo sapiens ] |
Official Symbol : | TG |
Synonyms : | TG; thyroglobulin; AITD3; TGN; |
Gene ID : | 7038 |
mRNA Refseq : | NM_003235 |
Protein Refseq : | NP_003226 |
MIM : | 188450 |
Uniprot ID : | P01266 |
Chromosome Location : | 8q24 |
Pathway : | Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; |
Function : | NOT carboxylesterase activity; chaperone binding; hormone activity; NOT neurexin family protein binding; NOT receptor activity; |
Products Types
◆ Recombinant Protein | ||
Tg-6386M | Recombinant Mouse Tg Protein, Myc/DDK-tagged | +Inquiry |
TG-708H | Recombinant Human TG Protein, MYC/DDK-tagged | +Inquiry |
Tg-2125R | Recombinant Rat Tg Protein, His-tagged | +Inquiry |
TG-2112R | Recombinant Rat TG Protein (21-300 aa), His-SUMO-tagged | +Inquiry |
TG-9158M | Recombinant Mouse TG Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
TG-22P | Native Porcine Thyroglobulin (TG) Protein | +Inquiry |
TG-37P | Native Porcine TG protein | +Inquiry |
TG-393H | Native Human Thyroglobulin | +Inquiry |
◆ Assay kits | ||
Kit-2277 | Transglutaminase Inhibitor Screening Assay Kit | +Inquiry |
Kit-0814 | Transglutaminase Activity Colorimetric Assay Kit | +Inquiry |
Kit-2036 | Triglyceride Colorimetric Assay Kit | +Inquiry |
Kit-0815 | Triglyceride Quantification Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Ask a questionCustomer Reviews (3)
Write a reviewEnhancing efficiency, the biomolecular reagent yields fast experimental results.
Suitable for long-term storage, the protein substance exhibits long-lasting stability.
Emphasizing product innovation, the manufacturer regularly introduces new protein reagents.
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