||Protein tyrosine phosphatase. (PTP-IA2, ICA-PTP IA2 gel512), Catalytic domain, (a.a. 693-979), with N-terminal GST tag, MW=58.8 kDa, expressed in an E.coli expression system.
||The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.
||25 mM Tris-HCl, pH 8.0, 75 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, and 10 mM glutathione.
||Suitable for use as an immunogen, in binding assays or as an antigen in autoimmune assays.
||>6 months at –80°C