Cat.No.:	PTPRN-457H
Product Overview:	Protein tyrosine phosphatase. (PTP-IA2, ICA-PTP IA2 gel512), Catalytic domain, (a.a. 693-979), with N-terminal GST tag, MW=58.8 kDa, expressed in an E.coli expression system.
Description:	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.
Source:	E.coli
Species:	Human
Tag:	GST
Form:	25 mM Tris-HCl, pH 8.0, 75 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, and 10 mM glutathione.
Purity:	≥ 95%
Applications:	Suitable for use as an immunogen, in binding assays or as an antigen in autoimmune assays.
Storage:	>6 months at –80°C

Gene Name:	PTPRN protein tyrosine phosphatase, receptor type, N [ Homo sapiens (human) ]
Official Symbol:	PTPRN
Synonyms:	PTPRN; IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP; protein tyrosine phosphatase, receptor type, N; receptor-type tyrosine-protein phosphatase-like N; ICA 512; PTP IA-2; islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N; EC 3.1.3.48
Gene ID:	5798
mRNA Refseq:	NM_002846
Protein Refseq:	NP_002837
MIM:	601773
UniProt ID:	Q16849
Chromosome Location:	2q35-q36.1
Pathway:	Type I diabetes mellitus
Function:	GTPase binding; protein binding; spectrin binding

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