Recombinant Human TNFSF15, His-tagged
Cat.No. : | TNFSF15-31532TH |
Product Overview : | Recombinant full length Human TL1A, secreted form with an N terminal His tag; 201 amino acids, Predicted MWt 22.7kDa. |
- Specification
- Gene Information
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Description : | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. |
Protein length : | 180 amino acids |
Conjugation : | HIS |
Molecular Weight : | 22.700kDa inclusive of tags |
Source : | E. coli |
Tissue specificity : | Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 50% Glycerol, 0.2M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0 |
Storage : | Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | MGSSHHHHHHSSGLVPRGSHMLKGQ EFAPSHQQVYAPLRADGDKPRAHLT VVRQTPTQHFKNQFPALHWEHELGL AFTKNRMNYTNKFLLIPESGDYFIY SQVTFRGMTSECSEIRQAGRPNKPD SITVVITKVTDSYPEPTQLLMGTKS VCEVGSNWFQPIYLGAMFSLQEGDK LMVNVSDISLVDYTKEDKTFFGAFL L |
Sequence Similarities : | Belongs to the tumor necrosis factor family. |
Gene Name : | TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 [ Homo sapiens ] |
Official Symbol : | TNFSF15 |
Synonyms : | TNFSF15; tumor necrosis factor (ligand) superfamily, member 15; tumor necrosis factor ligand superfamily member 15; MGC129934; MGC129935; TL1; TL1A; TNF ligand related molecule 1; TNF superfamily ligand TL1A; vascular endothelial cell growth inhibitor; va |
Gene ID : | 9966 |
mRNA Refseq : | NM_005118 |
Protein Refseq : | NP_005109 |
MIM : | 604052 |
Uniprot ID : | O95150 |
Chromosome Location : | 9q32 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Senescence and Autophagy, organism-specific biosystem; |
Function : | cytokine activity; death receptor binding; receptor binding; tumor necrosis factor receptor binding; |
Products Types
◆ Recombinant Protein | ||
TNFSF15-150HB | Recombinant Human TNFSF15 Trimer protein, N-His-Flag-tagged, Biotinylated | +Inquiry |
TNFSF15-326H | Active Recombinant Human TNFSF15 Protein (Gln58-Leu251), C-His tagged, Animal-free, Carrier-free | +Inquiry |
TNFSF15-17H | Recombinant Human TNFSF15 Protein, N-terminal His and AviTag™, Biotinylated | +Inquiry |
Tnfsf15-400M | Recombinant Mouse Tnfsf15 Protein, non-tagged | +Inquiry |
TNFSF15-5860R | Recombinant Rat TNFSF15 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
TNFSF15-1386RCL | Recombinant Rat TNFSF15 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionTNFSF15 interacts with receptors on immune cells, influencing their activity and contributing to the overall regulation of immune responses.
Several clinical trials are underway to evaluate the efficacy and safety of therapies targeting TNFSF15 in autoimmune diseases.
TNFSF15 levels may serve as a biomarker for certain autoimmune conditions, aiding in the diagnosis and monitoring of disease progression.
TNFSF15 is considered a promising target for drug development, and ongoing research aims to identify compounds that modulate its activity effectively.
In IBD, TNFSF15 is believed to be involved in the inflammation process, contributing to the chronic nature of the disease.
Customer Reviews (3)
Write a reviewThey keep up with the latest research findings and continually refine their product based on customer feedback and emerging scientific trends.
Their prompt assistance and prompt response can swiftly resolve any challenges, enabling smooth experimentation and maintaining the integrity of the results.
Their knowledgeable support team is well-equipped to address specific inquiries, suggest experimental protocols, and provide guidance throughout the entire research process.
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