"SIRT2" Related Products


Recombinant Human SIRT2, His-tagged

Cat. No. : SIRT2-463H
Product Overview : Recombinant Human SIRT2 (amino acids 13-319) was expressed in anE.coliexpression system with Cterminal His tag. MW=35.5 kDa.
Description : NAD-dependent deacetylase sirtuin-2 is an enzyme that in humans is encoded by the SIRT2 gene. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two transcript variants result from alternative splicing of this gene.
Source : E.Coli.
Formulated In : 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol, 3 mM DTT.
Application : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Purity : > 90%.
Stability : >6 months at -80°C.
Gene Name : SIRT2 sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) [ Homo sapiens ]
Synonyms : sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae); SIR2; SIR2L; SIR2L2; SIRT2; sirtuin 2; sirtuin type 2; sir2-related protein type 2; silent information regulator 2; silencing information regulator 2-like; EC 3.5.1.-; SIR2-like; SIR2-like protein 2; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2
Gene ID : 22933
mRNA Refseq : NM_012237
Protein Refseq : NP_036369
MIM : 604480
UniProt ID : Q8IXJ6
Chromosome Location : 19q13
Function : NAD binding; NAD+ ADP-ribosyltransferase activity; NAD-dependent histone deacetylase activity; histone acetyltransferase binding; histone deacetylase binding; hydrolase activity; metal ion binding; transcription factor binding; tubulin deacetylase activity; ubiquitin binding; zinc ion binding

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