Recombinant Human TP53BP1, His-tagged

• Cat.No.: TP53BP1-26025TH
• Product Overview: Recombinant fragment, corresponding to amino acids 1008-1972 of Human 53BP1 with N terminal His tag; 965 amino acids, 137kDa.

Specification

• Description: Tumor suppressor p53-binding protein 1 also known as p53-binding protein 1 or 53BP1 is a protein that in humans is encoded by the TP53BP1 gene.
• Conjugation: HIS
• Source: E. coli
• Form: Lyophilised:Reconstitute with 86 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Store at 4°C. Upon reconstitution store at -80oC.
• Sequences of amino acids: EKPATGERKNGSTAVAESVASPQKT MSVLSCICEARQENE ARSEDPPTTPIRGNLLHFPSSQGEE EKEKLEGDHTIRQ SQQPMKPISPVKDPVSPASQKMVIQ GPSSPQGEAMVTD VLEDQKEGRSTNKENPSKALIERPS QNNIGIQTMECSLRV PETVSAATQTIKNVCEQGTSTVDQN FGKQDATVQTERG SGEKPVSAPGDDTESLHSQGEEEFD MPQPPHGHVLHRH MRTIREVRTLVTRVITDVYYVDGTE VERKVTEETEEPIVECQECETEVSP SQTGGSSGDLGDISSFSSKASSLHR TSS GTSLSAMHSSGSSGKGAGPLRGKTS GTEPADFALPSSR GGPGKLSPRKGVSQTGTPVCEEDGD AGLGIRQGGKAPV TPRGRGRRGRPPSRTTGTRETAVPG PLGIEDISPNLSPDD KSFSRVVPRVPDSTRRTDVGAGALR RSDSPEIPFQAAA GPSDGLDASSPGNSFVGLRVVAKWS SNGYFYSGKITRD VGAGKYKLLFDDGYECDVLGKDILL CDPIPLDTEVTALSEDEYFSAGVVK GHRKESGELYYSIEKEGQRKWYKRM AVI LSLEQGNRLREQYGLGPYEAVTPLT KAADISLDNLVEG KRKRRSNVSSPATPTASSSSSTTPT RKITESPRASMGV LSGKRKLITSEEERSPAKRGRKSAT VKPGAVGAGEFVSPC ESGDNTGEPSALEEQRGPLPLNKTL FLGYAFLLTMATT SDKLASRSKLPDGPTGSSEEEEEFL EIPPFNKQYTESQ LRAGAGYILEDFNEAQCNTAYQCLL IADQHCRTRKYFLCLASGIPCVSHV WVHDSCHANQLQNYRNYLLPAGYSL EEQ RILDWQPRENPFQNLKVLLVSDQQQ NFLELWSEILMTG GAASVKQHHSSAHNKDIALGVFDVV VTDPSCPASVLKC AEALQLPVVSQEWVIQCLIVGERIG FKQHPKYKHDYVSH

Gene Information

• Gene Name: TP53BP1 tumor protein p53 binding protein 1 [ Homo sapiens ]
• Official Symbol: TP53BP1
• Synonyms: TP53BP1; tumor protein p53 binding protein 1; tumor protein p53 binding protein, 1; tumor suppressor p53-binding protein 1; 53BP1; p202
• Gene ID: 7158
• mRNA Refseq: NM_001141979
• Protein Refseq: NP_001135451
• MIM: 605230
• Uniprot ID: Q12888
• Chromosome Location: 15q15-q21
• Pathway: DNA Repair, organism-specific biosystem; Double-Strand Break Repair, organism-specific biosystem; Homologous Recombination Repair, organism-specific biosystem; Homologous recombination repair of replication-independent double-strand breaks, organism-specific biosystem; Recruitment of repair and signaling proteins to double-strand breaks, organism-specific biosystem
• Function: RNA polymerase II activating transcription factor binding; RNA polymerase II transcription cofactor activity; damaged DNA binding; p53 binding; protein binding