||Recombinant fragment, corresponding to amino acids 207-406 of Human TRAF4 with an N terminal His tag. Predicted MWt: 23kDa;
||This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined.
||Lyophilised:Reconstitute with 138 μl distilled water.
||Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
||Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
|Sequences of amino acids:
||IQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTA LVLCPFKDSGCKHRCPKLAMARHVEESVKPHLAMMCAL VSRQRQELQELRRELEELSVGSDGVLIWKIGSYGRRLQ EAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEG THLSLYIRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAK PQHVTE