| Cat.No.: | UGT1A7-31664TH |
| Product Overview: | Recombinant full length UGT1A7 protein (Human) |
| Description: | This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has moderate glucuronidase activity with phenols. |
| Tissue specificity: | Liver and gastric tissue. |
| Biological activity: | Vial Content: 5 mg protein.concentration 2-20 mg/mL protein |
| Form: | Liquid |
| Storage buffer: | Preservative: NoneConstituents: 20% Glycerol, 100mM Potassium phosphate, 1mM DTT, 0.1mM EDTA, pH 7.4 |
| Storage: | Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles. |
| Sequences of amino acids: | MARAGWTGLLPLYVCLLLTCGFAKAGKLLVVPMDGSHWFT MQSVVEKLILRGHEVVVVMPEVSWQLGRSLNCTVKTYSTS YTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLF FSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKY FSLPSVVFARGIFCHYLEEGAQCPAPLSYVPRLLLGFSDA MTFKERVWNHIMHLEEHLFCPYFFKNVLEIASEILQTPVT AYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQG KPVPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIA DALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKR METKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRL SSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGR VKKAHKSKTH |
| Sequence Similarities: | Belongs to the UDP-glycosyltransferase family. |
| Gene Name: | UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 [ Homo sapiens ] |
| Official Symbol: | UGT1A7 |
| Synonyms: | UGT1A7; UDP glucuronosyltransferase 1 family, polypeptide A7; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1-7; UGT1G; |
| Gene ID: | 54577 |
| mRNA Refseq: | NM_019077 |
| Protein Refseq: | NP_061950 |
| MIM: | 606432 |
| Uniprot ID: | Q9HAW7 |
| Chromosome Location: | 2q37 |
| Pathway: | Ascorbate and aldarate metabolism, organism-specific biosystem; Ascorbate and aldarate metabolism, conserved biosystem; Ascorbate biosynthesis, animals, glucose-1P => ascorbate, organism-specific biosystem; Ascorbate biosynthesis, animals, glucose-1P => |
| Function: | drug binding; enzyme binding; enzyme inhibitor activity; glucuronosyltransferase activity; protein heterodimerization activity; |
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