Recombinant Human PTPN11, GST-tagged, Active

• Cat.No.: PTPN11-461H
• Product Overview: Recombinant human PTPN11 (246-593) was expressed inE.colicells using a N-terminal GST tag. MW = 69 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 246-593 a.a.
• Description: Mammalian PTPases can be subdivided into 1 of 2 broad categories: transmembrane receptor PTPases and intracellular PTPases. PTPN11 is one of the 2 closely related mammalian intracellular PTPases whose sequences encode 2 tandem SRC homology 2 (SH2) domains that are located at the amino-terminal side of a single PTPase catalytic domain. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration.
• Sequence: 246-593.
• Applications: Phosphatase Assay, Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Publications:
  Decline in arylsulfatase B expression increases EGFR expression by inhibiting the protein-tyrosine phosphatase SHP2 and activating JNK in prostate cells (2018)

Gene Information

• Gene Name: PTPN11 protein tyrosine phosphatase, non-receptor type 11 [ Homo sapiens ]
• Synonyms: protein tyrosine phosphatase, non-receptor type 11; CFC; NS1; SHP2; BPTP3; PTP2C; PTP-1D; SH-PTP2; SH-PTP3; MGC14433; PTPN11; protein tyrosine phosphatase-2; protein-tyrosine phosphatase 2C; EC 3.1.3.48; PTP-2C; SHP-2; SHPTP2; Shp2; Noonan syndrome 1; Protein-tyrosine phosphatase 2C
• Gene ID: 5781
• mRNA Refseq: NM_002834
• Protein Refseq: NP_002825
• MIM: 176876
• UniProt ID: Q06124
• Chromosome Location: 12q24
• Pathway: Adipocytokine signaling pathway; Chronic myeloid leukemia; Epithelial cell signaling in Helicobacter pylori infection; Jak-STAT signaling pathway; Leukocyte transendothelial migration; Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway; Renal cell carcinoma
• Function: hydrolase activity; insulin receptor binding; insulin receptor substrate binding; non-membrane spanning protein tyrosine phosphatase activity; peptide hormone receptor binding; phospholipase binding; protein domain specific binding