Recombinant Human PTPN11, GST-tagged, Active
Cat.No. : | PTPN11-461H |
Product Overview : | Recombinant human PTPN11 (246-593) was expressed inE.colicells using a N-terminal GST tag. MW = 69 kDa. |
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Cat. No. : | PTPN11-461H |
Description : | Mammalian PTPases can be subdivided into 1 of 2 broad categories: transmembrane receptor PTPases and intracellular PTPases. PTPN11 is one of the 2 closely related mammalian intracellular PTPases whose sequences encode 2 tandem SRC homology 2 (SH2) domains that are located at the amino-terminal side of a single PTPase catalytic domain. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. |
Source : | E.coli. |
Sequence : | 246-593. |
Applications : | Phosphatase Assay, Western Blot. |
Storage And Stability : | Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Publication : |
Decline in arylsulfatase B expression increases EGFR expression by inhibiting the protein-tyrosine phosphatase SHP2 and activating JNK in prostate cells (2018)
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Gene Name : | PTPN11 protein tyrosine phosphatase, non-receptor type 11 [ Homo sapiens ] |
Synonyms : | protein tyrosine phosphatase, non-receptor type 11; CFC; NS1; SHP2; BPTP3; PTP2C; PTP-1D; SH-PTP2; SH-PTP3; MGC14433; PTPN11; protein tyrosine phosphatase-2; protein-tyrosine phosphatase 2C; EC 3.1.3.48; PTP-2C; SHP-2; SHPTP2; Shp2; Noonan syndrome 1; Protein-tyrosine phosphatase 2C |
Gene ID : | 5781 |
mRNA Refseq : | NM_002834 |
Protein Refseq : | NP_002825 |
MIM : | 176876 |
UniProt ID : | Q06124 |
Chromosome Location : | 12q24 |
Pathway : | Adipocytokine signaling pathway; Chronic myeloid leukemia; Epithelial cell signaling in Helicobacter pylori infection; Jak-STAT signaling pathway; Leukocyte transendothelial migration; Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway; Renal cell carcinoma |
Function : | hydrolase activity; insulin receptor binding; insulin receptor substrate binding; non-membrane spanning protein tyrosine phosphatase activity; peptide hormone receptor binding; phospholipase binding; protein domain specific binding |
Products Types
◆ Recombinant Protein | ||
Ptpn11-5235M | Recombinant Mouse Ptpn11 Protein, Myc/DDK-tagged | +Inquiry |
PTPN11-18H | Active Recombinant Human PTPN11 Protein, N-terminal 6XHis and AviTag™, Biotinylated | +Inquiry |
PTPN11-3522R | Recombinant Rhesus Macaque PTPN11 Protein, His (Fc)-Avi-tagged | +Inquiry |
PTPN11-04H | Active Recombinant Human PTPN11 Protein(Full length), N-GST-tagged | +Inquiry |
Ptpn11-8674M | Active Recombinant Mouse Ptpn11 protein(Met1-Arg593), His-tagged | +Inquiry |
◆ Lysates | ||
PTPN11-1334MCL | Recombinant Mouse PTPN11 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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