Recombinant Human GRB10, GST-tagged GRB10-1856H

Recombinant Human GRB10, GST-tagged

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Recombinant Human GRB10, GST-tagged

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Cat. No. : GRB10-1856H
Product Overview : Recombinant human GRB10 protein(637-926) with N-terminal GST tag was expressed inE.coliexpression system, MW=60.3 kDa.
Description : Growth factor receptor-bound protein 10 is a protein that in humans is encoded by the GRB10 gene. The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors.
Source : E.coli.
Purity : 90%.
Formulation : 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 20% glycerol, and 3 mM DTT.
Specific Activity : 4.6 U/ug. One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 37ºC. Assay buffer: 50 mM HEPES, pH 7.4, 2 mM EDTA, 3 mM DTT, 100 mM NaCl, 50 mM pNPP.
Application : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage : >6 months at –80°C.
PDB rendering based on 1nrv :

Gene Name : GRB10 growth factor receptor-bound protein 10 [ Homo sapiens ]
Synonyms : growth factor receptor-bound protein 10; RSS; IRBP; MEG1; GRB-IR; Grb-10; KIAA0207; GRB10; OTTHUMP00000197989; OTTHUMP00000197994; OTTHUMP00000197993;OTTHUMP00000197990; GRBIR;OTTHUMP00000197991; GRB10 adaptor protein; maternally expressed gene 1; insulin receptor-binding protein Grb-IR
Gene ID : 2887
mRNA Refseq : NM_001001549
Protein Refseq : NP_001001549
MIM : 601523
UniProt ID : Q13322
Chromosome Location : 7p12-p11.2
Function : SH3/SH2 adaptor activity; insulin receptor binding; protein binding

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